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心力衰竭的能量代谢重构及其治疗 被引量：32

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摘要 在心力衰竭发生发展的过程中,肥厚和衰竭的心肌往往发生了能量和底物代谢的改变,并直接或间接地促进了心肌重构的发展,即心肌的能量"代谢重构"。针对这一靶点,通过哌克昔林、曲美他嗪、左卡尼汀等药物抑制游离脂肪酸的摄取、β-氧化或直接促进葡萄糖代谢,均可能进一步优化心肌的能量底物代谢,更好地保存或改善心肌功能,延缓心力衰竭的进展。
作者 苏冠华 孙雨霏 卢永昕
机构地区 华中科技大学同济医学院附属协和医院心内科 武汉市普爱医院心内科
出处 《国际心血管病杂志》 2012年第2期65-67,共3页 International Journal of Cardiovascular Disease
基金 国家自然科学基金(30470457)
关键词 心力衰竭 能量代谢 肉碱脂酰转移酶 曲美他嗪 左卡尼汀
分类号 R541.6 [医药卫生—心血管疾病]
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参考文献21

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二级参考文献13

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  • 2中华医学会心血管病学分会 中华心血管病杂志编辑委员会.肺动脉高压筛查诊断与治疗专家共识[J].中华心血管病杂志,2007,35:979-987.
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  • 6Loster H, Miehe K, Punzel M, et al. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. Cardiovasc Drugs Ther, 1999, 13 : 537-546.
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共引文献14

同被引文献358

引证文献32

二级引证文献240

国际心血管病杂志
2012年 第2期

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