摘要
目的分析呼吸内科下呼吸道感染病原菌特点及耐药性,为临床用药提供指导和依据。方法回顾性分析82例下呼吸道感染患者的临床资料。结果共分离出87株病原菌,革兰阴性菌61株占70.1%,革兰阳性菌21株占24.1%,真菌5株占5.7%;检出率最高的4种病原菌为铜绿假单胞菌占21.8%、肺炎克雷伯菌占16.1%、金黄色葡萄球菌占16.1%和大肠埃希菌占12.6%;革兰阴性菌对头孢哌酮/舒巴坦、亚胺培南、美罗培南和头孢吡肟的耐药率较低,<22.0%;金黄色葡萄球菌对万古霉素、替考拉宁的耐药率为0,对其他抗菌药物均呈现出较高的耐药性。结论呼吸内科下呼吸道感染病原菌以革兰阴性菌为主,主要病原菌的耐药形式严峻,应加强耐药性监测。
OBJECTIVE To analyze the distribution and drug resistance of the pathogens causing lower respiratory tract infections in department of respiratory medicine and provide guidance and evidence for clinical medication.METHODS The clinical data of 82 cases with lower respiratory tract infections were retrospectively analyzed.RESULTS A total of 87 strains of pathogens were isolated,among which 61 strains of gram-negative bacteria accounted for 70.1%,21 strains of gram-positive bacteria accounted for 24.1%,and 5 strains of fungi accounted for 5.7%.The most predominant pathogens isolated were Pseudomonas aeruginosa with the detection rate of 21.8%,followed by Klebsiella pneumoniae（16.1%）,Staphylococcus aureus（16.1%）,and Escherichia coli（12.6%）.The resistance rates of gram-negative bacteria to cefoperazone/sulbactam,imipenem,meropenem,and cefepime were relatively low,22.0%;and the resistance rates of S.aureus to vancomycin and teicoplanin were 0 but were relatively high to other antibiotics.CONCLUSION Gram-negative bacteria are the predominant pathogens causing lower respiratory tract infections in department of respiratory medicine,and the drug resistance of the main pathogens is serious,thus monitoring of drug resistance should be strengthened.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第6期1287-1289,共3页
Chinese Journal of Nosocomiology
关键词
呼吸内科
下呼吸道感染
病原菌
耐药性
Respiratory medicine
Lower respiratory tract infection
Pathogens
Drug resistance
