摘要
多药物抵抗是药物治疗难治性癫痫的主要障碍。有研究表明，多药物转运子P糖蛋白的表达增加和活性增强，阻止抗癫痼药物进入大脑是多药物抵抗的主要机制。另外有研究发现P糖蛋白的表达和活性与谷氨酸盐／NMDA受体/COX-2信号途径有关，这可能成为新的解决癫痫多药物抵抗的靶点。
Multidrug resistance is a major obstacle in the chemotherapy of refractory epilepsy. P-glyco- protein, an efflux transporter, which may play an important role in refractory epilepsy. Some studies point out that increased P-glycoprotein expression and activity limit pharrnacotherapy with antiepilepfic drugs. Other studies indicate that glutamate released during seizures signals through the NMDA receptor and COX-2 to increase P-glycoprotein. These evidences may lead to a new therapy of drug-resistantepilepsy.
出处
《国际儿科学杂志》
2012年第2期180-182,共3页
International Journal of Pediatrics
关键词
多药物耐药
环氧化酶-2
P糖蛋白
难洽陛癫痫
Multidrug resistance
Cyclooxygenase-2
P-glycoprotein
Refractory epilepsy
