摘要
目的探讨天然维生素E胶丸治疗黄褐斑的有效性,并观察其安全性。方法采用多中心、随机、开放临床研究的方法,对79例黄褐斑患者应用天然维生素E胶丸100mg,3次/d,口服治疗,疗程12周,并在治疗第4周,8周和12周随访,按照MASI评判标准评价皮损消退情况。结果治疗前、治疗后4周、8周与12周MASI评分比较差异均有统计学意义(P均<0.001),有效率为81.01%,约1/5的患者在治疗第4周皮损出现改善,且半数以上的患者在治疗第8周取得明显治疗效果,临床观察期间未发现任何明显的不良反应。结论使用天然维生素E胶丸治疗黄褐斑是安全有效的方法。
Objective To evaluate the efficacy and safety of vitamin E for the treatment of chloasma. Methods A muhi-center,randomized and open clinical study was conducted. Seventy-nine patients with chloasma were treated with oral vitamin E 100mg,3 times daily for 12 weeks. In the treatment of 4 weeks,8 weeks and 12 weeks respectively, the subside and efficacy of skin lesions in patients were evaluated by MASI （melasma area and severity index） evaluation standard. Results Before and after treatment for 4 weeks,8 weeks and 12 weeks, the difference of MASI score were significant （P〈 0.001）. The total effective rate was 81.01%, about 1/5 of patients improved in the fourth weeks of treatment,and more than half of the patients obtained apparent effect in the treatment of eighth week. No serious adverse effect was foud during the observation. Conclusion The treatment for melasma with vitamin E is safe and effective.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2012年第4期367-368,共2页
The Chinese Journal of Dermatovenereology
