摘要
用高度抗氯喹约氏疟原虫 Ac—1虫株感染小鼠观察了酮替芬及赛庚啶对氯喹抗药性的逆转作用,1/4治疗剂量的酮替芬及赛庚啶己可使抗氯喹特性被逆转,使抗性虫感染小鼠被敏感株治疗剂量所治愈。提高剂量杀虫作用加强。异博定相应的效果较差且毒性较高。预先或同时加服蛋白质合成抑制剂氯霉素或利福平则未观察到对氯喹抗药性有逆转作用。作者对临床上用氯喹常规剂量合并酮替芬或赛庚啶治疗对氯喹抗药性病人的问题进行了讨论,提出进一步合并加服周效磺胺或具作用类似物可能取得更好的数果。氯代丙咪嗪等则被建议用于研究。
250mg/kg/d×4 chloroquine phosphate(CQ)could not stop the growth of the highly chloroquine resistant strain AC-1 P.yoelii,which was used in this research.When i/4 dosage for curing,10mg/kg/d ketotifen or cyproheptadine was given orally combining 250mg/kg/d or lomg/kg/d CQ,the number of the parasites decreased rapidly and the patasitemia of the Ac-1 infected mice turned negative in both cases.But some recrude- scent cases were found in lomg/kg/d CQ combination group within one week,but better result could be obtained if the dosage of ketotifen or cyproheptadine increased. 100mg/kg/d×4 verapamil combined CQ was tried in the same way,although at thes dosage verapamil was almost intolerable,less than 50% infected mice showed negativr parasitemia. Protein synthesis inhibitor chloromycine and rifampin were given two days earliei or at the same time of CQ administration,but no obvious reversive effect could be found. Considering the CQ resistance of the plasmodium was net based on only one mechanism,the importance of the synergic effect of the plasmodicidal fanction of ksto- tifen or cyproheptadine and CQ in addition to their reversive effect was emphasized, and a further combination with sulfadoxine was suggested based on the same reasor. According to previous finding,compounds with chemical structure belonging to the formula:Cl-cyelo structure-polyamine structure,would be plasmodicidal,so chloro— desipramine was suggested to be tried.
出处
《中国寄生虫病防治杂志》
CSCD
1990年第3期194-197,共4页
Chinese Journal of Parasitic Disease Control
