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线粒体相关的疾病治疗及干预策略 被引量：3

Therapeutic and tampering approaches for mitochondrial associated diseases
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摘要 线粒体疾病是一种累及不同的组织和器官的复杂异质性疾病,由核基因或线粒体基因的遗传缺陷导致,同时也受环境因素的影响。近十年来,有关线粒体疾病的诊断及发生机制的研究进展迅速,而疾病的治疗方法却研究较少。着重介绍线粒体疾病的相关治疗方法和干预策略。 As heterogeneous disorders,mitochondrial diseases can affect various tissues and organs.They can be caused by genetic defects（nuclear and mitochondrial DNA） or environmental factors.Last decades,substantial progress has been made among the diagnosis and pathogenesis of mitochondrial diseases.However,there have been not many reports about development of therapies approaches for these disorders.In this review article,we will discuss emerging therapeutic and intervention strategies of mitochondrial diseases.
作者 郑斌娇 梁敏 薛凌 郑静 张婷 龚莎莎 方芳 吕建新 管敏鑫
机构地区 温州医学院 浙江大学生命科学学院
出处 《生命科学》 CSCD 2012年第2期185-190,共6页 Chinese Bulletin of Life Sciences
基金 国家重点基础研究发展计划(“973”项目)(2004CCA02200) 浙江省医药卫生科学研究基金项目(2006A100) 浙江省“钱江人才计划”择优资助项目(2006R10021) 浙江省重大科技专项社会发展项目(2007C13021) 浙江省研究生创新科研项目(YK2010084)
关键词 线粒体疾病 基因治疗 氧化磷酸化缺陷 异质性 mitochondrial diseases gene therapy oxidative phosphorylation defects heteroplasmy
分类号 R589 [医药卫生—内分泌] R363 [医药卫生—病理学]
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参考文献59

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同被引文献46

  • 1Thorbum DR, Dah HH. Mitochondrial disorders: genetics, counseling, prenatal diagnosis and reproductive options. Am J Med Genet, 2001, 106(1):102-14.
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生命科学
2012年 第2期

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