摘要
应用香豆素治疗下肢象皮肿56例,每人每日服400mg,连服367d,不绑扎患肢。56条腿治疗中与治疗毕腿径平均比治前分别缩小4.2%和6.5%,还原率治疗中平均为43.4%,治毕平均为68.1%。56例患者治疗半年时基本治愈率为25.0%,显效与有效率分别为7.1%和67.9%;治毕时基本治愈率为28.6%,显效与有效率分别为12.5%和58.9%。对照组病人服安慰剂后均不见好转,且有5例患肢继续增粗。停服香豆素后半年随访54例,疗效巩固,腿径比治前缩小7.2%。长期口服香豆素并无不良反应,用于治疗丝虫性象皮肿优于以往试用的其他疗法,患者在家服药不影响劳动生产,值得推广试用。
Fifty-six cases with various stages of filarial elephantiasis at unilateral lower extremities were treated with coumarin at the dosage of 400mg orally once a day for 367 consecutive days and no bandage was used for the diseased legs。The 56 diseased legs were markedly improved through treatment;with a mean recovery rate of 68.1%. Sixteen cases(28.6%)were cured,the total effective rate was 100%.The results revealed that coumarin was highly effective in the treatment of filarial elephantiasis.
出处
《中国寄生虫病防治杂志》
CSCD
1990年第1期8-12,共5页
Chinese Journal of Parasitic Disease Control
基金
本项研究得到联合国开发计划署/世界银行/世界卫生组织热带病研究培训特别规划处的资助~~
