摘要
磷酸咯萘啶1.2g、磺胺多辛1.5g,伯喹67.5mg 伍用;磷酸咯萘啶0.8g 与磺胺多辛乙氨嘧啶复合片伍用,在抗氯喹恶性疟流行区分别治疗恶性疟34例和32例,治后平均退热时间分别为35.5±19.1h、37.3±17.6h,平均疟原虫无性体转阴时间为58±15.3h、59.8±18.9h,一个月内复燃率为6.5%、13.3%。前者清除配子体时间为5.4±3.7d,服药后配子体出现率17.4%,并能阻止恶性疟原虫在蚊体内的有性繁殖。后者无此作用。
Thirty-four cases with falciparum malaria were treated jointly with pyronari- dine phosphate (1.2g base),sulfadoxine(1.5g base) and primaquine(67.5mg base) in 3 days in the chloroquine resistant areas of Mengla and Jinghong Counties,Yunnan Province.While another group of 32 cases were treated combinedly with pyronaridine phosphate malaridine (0.8g),sulfadoxine (1.0g) and pyrimethamine (50mg) in 2 days. The average defervescent time of the 2 combined therapies were 35.5±19.1h and 37.3± 17.6h;the mean asexual parasite clearance time 58±15.3h and 50.8±18.9h respectively. The recrudescence rate of the 2 groups were found to be 6.5% and 13.3% after a follow- up of one month.With the former combined therapy,the gametocyte-clearance time was 5.4±3.7d,the sexual reproductions of the parasites in Anopheles mosquitos were restrained,which was not found when the later therapy was used.No noticeable side effects were observed in both therapies.
出处
《中国寄生虫病防治杂志》
CSCD
1990年第1期24-26,共3页
Chinese Journal of Parasitic Disease Control
