摘要
目的探讨腹部创伤患者腹腔引流液可溶性髓系细胞触发受体-1（sTREM-1）的表达及其对腹部创伤后脓毒症的诊断价值。方法将本院ICU收治的65例腹部创伤患者作为病例组，18例胃大部切除术（择期手术）后患者作为对照组，分别检测两组患者入ICU后0、24、48、72h腹腔引流液sTREM-1、血清sTREM-1、前降钙素（PCT）和C反应蛋白（CRP）浓度，评价上述指标对创伤后脓毒症的早期诊断价值。结果创伤组腹腔引流液sTREM-1、血清sTREM-1、PCT和CRP浓度明显高于对照组（P〈0．05）。创伤组中并发脓毒症组腹腔引流液sTREM-l、血清sTREM-1、PCT和CRP浓度明显高于未并发脓毒症组（P〈0．05），腹腔引流液sTREM-1诊断创伤后脓毒症的敏感性82．5％，特异性84．0％，ROC曲线下面积0．885，明显优于血清sTREM-1、PCT及CRP（P〈0．05）。结论腹腔引流液sTREM-1对腹部创伤后脓毒症的早期诊断有重要价值。
Objective To investigate the expression of soluble triggering receptors expressed on myeloid cells 1 （ sTREM 1 ） and its diagnostic value for sepsis in the patients with abdominal trauma. Methods 65 patients with abdominal trauma were admitted to trauma group, 18 gastrectomy patients to the control group, who hospitalized in our hospital. The sTREM 1 in the drainage fluid and blood, procalcitonin （PCT） and high sensitivity C reactive protein （CRP） levels in blood were examined at 0, 24,48,72 hours after admission, and the early diagnosis value of the above mentioned indexes was evaluated for post traumatic sepsis. Results The levels of drainage fluid sTREM 1, plasma sTREM 1, PCT and CRP in trauma group were significantly higher than those in control group （ P 〈 0. 05 ）. The levels of drainage fluid sTREM 1, plasma sTREM 1, PCT and CRP were significantly higher in sepsis group than in nonsepsis group （ P 〈 0.05 ）. The drainage fluid sTREM l had a sensitivity of 82.5% ,specificity of 84.0% to the septic patients with abdominal trauma, the area under the ROC curve was 0. 885, which was better than plasma sTREM 1, PCT and CRP. Conclusion Drainage fluid sTREM 1 has an important diagnostic value in the septic patients with abdominal trauma at the early stage.
出处
《中国急救医学》
CAS
CSCD
北大核心
2012年第3期196-199,共4页
Chinese Journal of Critical Care Medicine
基金
绍兴市社会发展重点科研项目（No.2010012）
关键词
可溶性髓系细胞触发受体-1
腹部创伤
脓毒症
前降钙素
超敏C反应蛋白
Soluble triggering receptors expressed on myeloid cells 1
Abdominal trauma
Sepsis
Procalcitonin （PCT）
High sensitivity C - reactive protein （CRP）
