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鼻咽癌患者血浆EBV DNA、VCA-IgA的检测意义 被引量：4

Significance of Detecting Plasma EBV DNA and VCA-IgA in Patients with Nasopharyngeal Carcinoma
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摘要 [目的]探讨鼻咽癌患者血浆EBV DNA、VCA-IgA的检测意义。[方法]采用荧光定量PCR技术检测血浆EBV DNA水平,常规免疫酶法检测VCA-IgA抗体滴度,分别检测168例初诊鼻咽癌患者和健康对照者60人的血液标本。[结果]鼻咽癌患者血浆EBV DNA、VCA-IgA阳性率分别为34.52%(58/168)和62.50%(105/168),均明显高于健康对照者的3.33%(2/60)和6.67%(4/60)(P均<0.01);两者联合检测的敏感度显著高于单一指标检测(P<0.05)。治疗后EBVDNA及VCA-IgA阳性率均明显低于治疗前(P<0.01);肿瘤残余组患者血浆EBV DNA、VCA-IgA阳性率明显高于肿瘤完全消退组及健康对照组(P<0.01)。[结论]血浆EBV DNA、VCA-IgA联合检测在鼻咽癌诊断、近期疗效判定方面有重要价值。
作者 朱焕锋 何侠
机构地区 江苏省肿瘤医院
出处 《肿瘤学杂志》 CAS 2012年第2期111-113,共3页 Journal of Chinese Oncology
基金 江苏省自然科学基金(BK2008479)
关键词 鼻咽肿瘤 EBV DNA VCA-IGA 诊断
分类号 R730.43 [医药卫生—肿瘤] R739.63 [医药卫生—肿瘤]
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参考文献9

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共引文献13

同被引文献40

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引证文献4

二级引证文献19

肿瘤学杂志
2012年 第2期

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