摘要
Background Various methods can be applied to build predictive models for the clinical data with binary outcome variable. This research aims to explore the process of constructing common predictive models, Logistic regression （LR）, decision tree （DT） and multilayer perceptron （MLP）, as well as focus on specific details when applying the methods mentioned above： what preconditions should be satisfied, how to set parameters of the model, how to screen variables and build accuracy models quickly and efficiently, and how to assess the generalization ability （that is, prediction performance） reliably by Monte Carlo method in the case of small sample size.
Background Various methods can be applied to build predictive models for the clinical data with binary outcome variable. This research aims to explore the process of constructing common predictive models, Logistic regression （LR）, decision tree （DT） and multilayer perceptron （MLP）, as well as focus on specific details when applying the methods mentioned above： what preconditions should be satisfied, how to set parameters of the model, how to screen variables and build accuracy models quickly and efficiently, and how to assess the generalization ability （that is, prediction performance） reliably by Monte Carlo method in the case of small sample size.
基金
This work was supported by the grants from National Natural Science Foundation of China （No. 21003077）, College of Public Health of Tianjin Medical University in China （No. GWKY-2010-01）, the Open Project of Key Laboratory of Advanced Energy Materials Chemistry （No. KLAEMC- OP201101） and Natural Science Foundation of Tianjin China （No. 08JCZDJC21400）.
