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心肌缺血后处理实验模型 被引量：1

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摘要 心肌缺血后处理（ischemic postconditioning,IPost）是通过在缺血心肌再灌注前施加一定的干预,激发机体内源性保护机制,以达到心肌保护,减少缺血再灌注损伤的一种措施.后处理是在缺血预处理（ischemic preconditioning,IPc）[1]之后,心肌保护研究的一个热点,多家机构在不同动物模型上,证实心肌IPost在减少再灌注早期心律失常的发生,改善心功能,缩小梗死面积,减少细胞凋亡等方面起到保护作用[2-3].
作者 付长江 郭立新 刘苏
机构地区 河北省邢台市第三医院心外科 河北医科大学第二医院心外科
出处 《河北医科大学学报》 CAS 2012年第1期119-122,共4页 Journal of Hebei Medical University
关键词 心肌缺血 模型 动物 综述文献
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1MURRY CE,JENNINGS RB,REIMER KA,et al.Preconditioning with ischemia:a delay of lethal cell injury in ischemic my-ocardium[J].Circulation,1986,74(5):1124-1136.
  • 2TSANG A,HAUSENLOY DJ,MOCANU MM,et al.Postconditioning:a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-Kinase-Akt pathway[J].Circulation Research,2004,95(3):230-232.
  • 3GALAGUDZA M,KURAPEEV D,MINASIAN S,et al.Ischemic postconditioning:brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm[J].Eur J Cardiothorac Surg,2004,25(6):1006-1010.
  • 4VINTEN-JOHANSEN J,ZHAO ZQ,JIANG R,et al.Myocardial protection in reperfusion with postconditioning[J].Expert Rev Cardiovasc Ther,2005,3(6):1035-1045.
  • 5LECOUR S,MAUPOIL V,SIRI O,et al.Activation of protective survivor activating factor enhancement(SAFE) pathway against reperfusion jnjury:Does it go beyond the RISK pathway?[J].Jmol Cell Cardiol,2009,47(1):32-40.
  • 6LACERDA L,SOMERS S,OPIE HL,et al.Ischemic postconditioning protects agaist reperfusion injury via the SAFE pathway[J].Cardivase Res,2009,84(2):201-208.
  • 7GUO Y,WU WJ,QIU YM,et al.Demonstration of an early and a late phase of ischemic preconditioning in mice[J].Am J Physiol,1998,275(6pt2):1375-1387.
  • 8LIU XD,YUAN ZL,HUANG DM,et al.An experimental study on protective effects of nonwound ischemic postconditioning to ischemia/reperfusion myocardial injury of rats[J].J Gui Yang Med Coll,2004,29(1):127-129.
  • 9KERENDI F,KIN H,HALKOS ME,et al.Remote postconditioning.Brief renal ischemia and reperfusion app-lied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine recaptors[J].Basic Res Cardiol,2005,100(5):404-412.
  • 10KIN H,ZHAO ZQ,SUN HY,et al.Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion[J].Cardiovasc Res,2004,62(1):74-85.

二级参考文献23

  • 1Holly TA, Drincic A, Byun Y, et al. Caspeae inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardial, 1999, 31 : 1709-1715.
  • 2Wolf B, Schuler M, Echeverri F, et al. Caspa-3 in the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor -45/inhibitor of Caspase-activated Dnase inactivation. J Biol Chem, 1999,274: 30651-30656.
  • 3Perea LP, Waldmann TA. Activation of human moyocytes induces differential resistance to apoptosis with rapid down regulation of Caspase-8/FLICE. Proc Natl Acad Sci USA, 1998, 95:14308-14313.
  • 4Beeker LC, Ambrosio G. Myocardial consequences of reperfusion. Prog Cardiovase Dis, 1987, 30:23-41.
  • 5Ambrosio G, Tritto I, Chiariello M. The role of oxygen free radicals in preconditioning. J Mol Cell Cardiol, 1995, 27:1035-1039.
  • 6Bolli R. Basic and clinical aspects of myocardial stunning. Prog Cardiovasc Dis, 1998, 40:477-516.
  • 7Bolli R, Patel B. Factors that determine the occurrence of reperfusion arrhythmias.Am Heart J, 1988,115:20-29.
  • 8Cave AC, Collis CS, Downey JM, et al. Improved functional recovery by ischemic preconditioning is not mediated by adenosine in the globally ischemic isolated rat heart.Cardiovasc Res, 1993, 27:663-670
  • 9Verma S, Fedak PW, Weisel RD, et al. Fundamentals of reperfusion injury for the clinical cardiologist. Circulation, 2002,105:2332-2336.
  • 10Piper HM, Abadallah Y, Schafer C. The first minutes of repedusion: A window of opportunity for cardioprotection. Cardiovasc Res, 2004, 61 :365-371

共引文献54

同被引文献19

  • 1Vinten-Johansen J,Zhao ZQ,Jiang R,et al.Myocardial protection in reperfusion with postconditioning[J].Expert Rev Cardiovasc Ther,2005,3(6):1035-1045.
  • 2Murry CE,Jnnnings RB,Reimer KA,et al.Preconditioning with ischemia:a delay of lethal cell injury in ischemic myocardium[J].Circulation,1986,74(5):1124-1136.
  • 3Kin H,Zhao ZQ,Sun HY,et al.Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion[J].Cardiovasc Res,2004,62(1):74-85.
  • 4Zhao ZQ,Corvera JS,Halkos ME,et al.Inhibition of myocardial injury by ischemic postconditioning during reperfusion:comparison with ischemic preconditioning[J].Am J Physiol Heart Circ Physiol,2003,285(2):H579-588.
  • 5Halkos ME,Kerendi F,Corvera JS,et al.Myocardial protection with postconditioning is not enhanced by ischemic preconditioning[J].Ann Thorac Surg,2004,78(3):961-969.
  • 6Bopassa JC,Ferrera R,Gateau-Roesch O,et al.PI3-kinasc regulates the mitochondrial transition pore in controlled reperfusion and postconditioning[J].Cardiovasc Res,2006,69(1):178-185.
  • 7Argaud L,Gateau-Roesch O,Raisky O,et al.Postconditioning inhibits mitochondrial permeability transition[J].Circulation,2005,111(2):194-197.
  • 8Yang XM,Philipp S,Downey JM,et al.Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation[J].Basic Rcs Cardiol,2005,100(1):57-63.
  • 9Darling CE,Jiang R,Maynar DM,et al.Postconditioning via stuttering reperfusion limits myocardial infact size in rabbit hearts:role of ERK1/2[J].Am J Physiol Heart Circ Physiol,2005,289(4):1618-1626.
  • 10Kisseleva T,Bhattacharya S,Braunstein J,et al.Signaling through the JAK/STAT pathway,recent advances and future challenges[J].Gene,2002,285 (1-2):1-24.

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河北医科大学学报
2012年 第1期

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