摘要
目的观察右美托咪啶(dexmedetomidine,DXM)抑制气管插管诱发患者心血管反应的临床效果。方法全身麻醉下行择期腹部手术患者40例,随机分为DXM组(试验组)和对照组,每组20例。试验组在麻醉前使用微泵静脉输注盐酸DXM,速率为1μg/kg(10min泵完);对照组以同样方式输注等量生理盐水,然后进行麻醉,咪唑安定0.1mg/kg、芬太尼4μg/kg、维库溴铵0.1mg/kg及依托眯酯0.3mg/kg顺序给药,气管插管后行机械通气。记录2组给药前、后,插管前、插管时,插管后1、3、5min的收缩压(systolic blood pressure,SBP)、舒张压(diastolicblood pressure,DBP)、平均动脉压(mean arterial pressure,MAP)、心率(heart rate,HR)进行分析比较。结果 2组患者插管时,插管后1、3、5min的SBP、DBP、MAP、HR均较给药前、后有不同程度波动,但试验组的波动程度明显低于对照组(P<0.05)。无不良反应发生。结论 DXM能显著抑制气管插管时的心血管反应。
Objective To observe the clinicl effects of dexmecdetomidine on cardiovascular response to tracheal intubation during general anesthesia. Methods Forty patients scheduled for elective operations under general anesthesia, were randomly assigned to receive either intravenous infusion of 1 μg/ kg dexmedetomidine （ dexmedetomidine group, n = 20 ） or intravenous infusion of the same amount of normal saline （ control group, n = 20 ）. Anesthesia was induced with midazolam 0.1 mg/kg, fentany 1 μg/ kg,veeuronium 0.1mg/kg and etomidate 0. 3mg/kg in both groups. Systolic blood pressure （SBP）, diastolic blood pressure （DBP） and heart rate （HR）were recorded before infusion, after infusion, before in dexmedetomidine group was smaller than that in control group （P 〈 0. 05 ）. Conclusion Dexmedetomidine can effectively inhibit cardiovascular responses to tracheal intubation during general anesthesia.
出处
《河北医科大学学报》
CAS
2012年第1期59-61,共3页
Journal of Hebei Medical University
关键词
右美托咪啶
插管法
气管内
心血管生理现象
dexmedetomidine
intubation, intratracheal
cardiovascular physiologic phenomena
