期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

ω-转氨酶制备手性胺的研究进展 被引量：3

Progress in ω-transaminase in chiral amine synthesis
在线阅读 下载PDF
导出
摘要 简要介绍了ω-转氨酶的催化机理、菌株来源以及目前国内外利用ω-转氨酶催化拆分或合成手性胺类化合物的研究进展。阐述了转氨酶生产手性胺中遇到的问题与解决方法,同时介绍了ω-转氨酶的固定化研究情况。最后对ω-转氨酶的发展前景进行了展望。 The reaction mechanism, sources of wild transaminase in chiral amine synthesis or resolution are production and the corresponding resolutions are described prospects of ω-transaminase is put forward as well. strain of ω-transaminase and recent developments of ω- briefly introduced. The problems in the ω-transaminase The immobilization of ω-transaminase is summarized. The
作者 贾红华 朱清禾 李艳 马莹莹 贾黎莎 韦萍
机构地区 南京工业大学生物与制药工程学院
出处 《现代化工》 CAS CSCD 北大核心 2012年第3期16-20,22,共6页 Modern Chemical Industry
基金 国家“973”计划项目(2009CB724700) 国家自然科学基金项目(20906048) 江苏高校优势学科建设工程资助项目
关键词 ω-转氨酶 手性胺 生物催化与转化 ω-transaminase chiral amine biocatalysis and biotransformation
分类号 TQ126.3 [化学工程—无机化工]
  • 相关文献

参考文献31

  • 1郭跃平,应向贤,赵冉冉,汪钊.酶法制备手性芳香胺化合物的研究进展[J].化工进展,2010,29(4):728-732. 被引量：5
  • 2Nugent T C.Chiral Amine Synthesis:methods,development and applications[M].WILEY-VCH,2010:431-455.
  • 3Koszelewski D,Tauber K,Faber K,et al.omega-Transaminases for the synthesis of non-racemic alpha-chiral primary amines[J].Trends in Biotechnology,2010,28(6):324-332.
  • 4Shin J S,Kim B G.Comparison of the omega-transaminases from different microorganisms and application to production of chiral amines[J].Biosci Biotechnol Biochem,2001,65 (8):1782-1788.
  • 5Shin J S,Yun J,Jang J W,et al.Purification,characterization,and molecular cloning of a novel amine:Pyruvate transaminase from Vibrio fluvialis JS17[J].Applied Microbiology and Biotechnology,2003,61 (5/6):463-471.
  • 6Cho B K,Park H Y,Seo J H,et al.Redesigning the substrate specificity of omega-aminotransferase for the kinetic resolution of aliphatic chiral amines[J].Biotechnology and Bioengineering,2008,99(2):275-284.
  • 7Yun H,Lim S,Cho B K,et al.Omega-amino acid:Pyruvate transaminase from Alcaligenes denitrificans Y2k-2:a new catalyst for kinetic resolution of beta-amino acids and amines[J].Applied and Environmental Microbiology,2004,70 (4):2529-2534.
  • 8Iwasaki A,Yamada Y,Kizaki N,et al.Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp.KNK168[J].Appl Microbiol Biotechnol,2006,69 (5):499-505.
  • 9Hanson R L,Davis B L,Chen Y,et al.Preparation of (R)-amines from racemic amines with an (S)-amine transaminase from Bacillus megaterium[J].Advanced Synthesis & Catalysis,2008,350 (9):1367-1375.
  • 10Kaulmann U,Smithies K,Smith M E B,et al.Substrate spectrum of omega-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis[J].Enzyme and Microbioal Technology,2007,41 (5):628-637.

二级参考文献26

  • 1徐刚,戴军强,吴坚平,杨立荣.有机相中酶催化1-苯基乙胺的不对称酰胺化反应[J].化工学报,2007,58(7):1741-1745. 被引量：5
  • 2Wen Sai, Tan Tianwei, Yu Mingrui. Immobilized lipase YlLip2- catalyzed resolution of (±) α-phenylethylamine in a medium with organic cosolvent[J]. Process Biochem., 2008, 43: 1259-1264.
  • 3Cammenberg M, Hult K, Park S.Molecular basis for the enhanced lipase-catalyzed N-acylation of 1 -phenylethanamine with methoxyacetate[J]. Chem. Biochem., 2006, 7: 1745-1749.
  • 4Blaser H U, Spindler F, Studer M. Enatioselective catalysis in fine chemical production[J]. Appl.Catal.A Gen., 2001, 221: 119-143.
  • 5Clifton, J E, Collins I, Hallett P, et al. Arylethanolamines derived from salicylamide with α-and β-adrenoceptor blocking activities. preparation of labetalol, its enantiomers, and related salic ylamides[J]. J. Med. Chem., 1982, 25: 670-679.
  • 6Jacques J, Collett A, Wilen S. Enantiomers, Racemates, and Resolutions[M]. New York: Wiley-lnterscience, 1980.
  • 7Itsuno S, Matsumoto T. Enantioselective reduction of oxime ethers with borane catalyzed by polymersupported 2-piperazinemethanol[J]. J. Org. Chem., 2000, 65: 5879-5881.
  • 8Mereyala H B, Pola P. Resolution of 1-arylethylamines with 5-(1,2-o-isopropylidene-3,6-anhydro-2-D-glucofuranosyl) hydrogen phthalate[J]. Tetrahedron: Asymmetry, 2003, 14: 2683-2685.
  • 9Iwasaki A, Yamada Y, Kizaki N, et al. Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp.KNK168[J]. Appl. Microbiol. Biotechnol., 2006, 69: 499-505.
  • 10Shin J S, Kim B G. Asymmetric synthesis of chiral amines with ω-transaminase[J].Biotechnol.Bioeng., 1999, 65 (2): 206-211.

共引文献4

同被引文献8

引证文献3

二级引证文献3

现代化工
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部