摘要
研究目的：研究半月板全切对膝关节软骨的影响，从而为临床治疗半月板损伤方法的选择提供理论依据；研究方法：采用动物实验方法，在克膝关节采用内侧半月板切除术式，应用组织学，组织化学，免疫组化，扫描电镜，同位素标记放射自显影等方法观察术后，5、10、15、20、25和30d膝关节的关节软骨变化；主要结果和结论：兔内侧半月板切除后，导致关节不合槽运动，早至5d即可发现关节软骨细胞和蛋白多糖改变，并随时间的延长而进行性加重。但软骨表面的玻溃，胶原网架的断裂则迟至术后20d出现。因此，半月板切除可导致肯关节病的发生，而软骨细胞的改变是导致骨关节病发生和发展的关键因素；建议：对运动员半月板损伤应尽早处理，尽量不采用全切的术式，应用关节镜对半月板成形，缝合可最大程度地降低由于半月板损伤对膝关节造成的不良影响。
Purpose of the study: Influences of total meniscectomy on articular cartilage of knee is studied to provide theo-retical basis for selection of treatment methods for meniscus injury. Methods: by means of animal experiment on rabbits,after 5, 10, 15, 20, 25 and 30 days of total medial meniscectomy, the articular cartilage of knee was observed with themethods of histology, histochemistry, immuno - histochemistry, scanning electron-microscope and autoradiography. Re-sults and conclusions: As early as 5 days after total medial meniscectomy, there were changes of chondrocytes and pro-teoglycan caused by unmatched movement of joint surfaces, these changes became more serious along with the extensionof the pathological course. However, the deterioration of cartilage surface and the rupture of collagen network were onlyfound after 20 days of operation. There fore osteoarthritis could be induced by total meniscectomy and the changes ofchondrocytes were the key factor to cause and develop osteoarthritis. Suggestion: For the injury of meniscus in athletes it should be treated in early stage, total meniscectomy is not a good way to treat such kind of injury. It is recommended that menisplasty or suture of meniscus should be done arthroscopically in order to avoid the negative influence on the knee by injury of meniscus.
出处
《体育科学》
CSSCI
北大核心
2000年第2期50-54,共5页
China Sport Science
关键词
半月板切除
半节软骨
膝关节
病理
运动损伤
meniscus
meniscectomy
articular cartilage
osteoarthritis
arthroscope
