摘要
1-(3-氟苯)-2-溴-1-丙酮在非质子极性溶剂中经胺化、环合反应,最后酸化,得到3-甲基-5-苯基-2-(3-氟基苯基)吗啉盐酸盐,总收率为70.6%。目标化合物结构经IR、1H NMR、MS测试技术确证。参照Porsolt法,使用小鼠强迫游泳药理实验模型,对所合成的化合物进行抗实验性抑郁药理活性研究。结果显示,此化合物具有良好的抗抑郁活性,值得进一步研究。
3-Methyl-5-phenyl-2-（3-fluorophenyl）morpholine hydrochloride was synthesized from 2-bromo-1-（3-fluorophenyl）-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidified by divergent synthetic method,with yield of 70.6%.Its structure was confirmed by IR and 1H NMR.Their antidepressant activities were tested with mice forced swimming test.The compound is worth to the further investigate in antidepressant activity.
出处
《应用化工》
CAS
CSCD
2012年第2期227-228,236,共3页
Applied Chemical Industry
基金
湖南省科技厅资助课题(04SK3053-3)
关键词
苯基氨基乙醇
吗啉盐酸盐
合成
抗抑郁活性
aminophenylalcohol
arylmorpholine
synthesis
antidepressant activity
