摘要
对于原发性局限性胃肠间质瘤（GIST）．外科手术结合术后伊马替尼辅助治疗已成为中高危患者的治疗共识。而对于一些手术切除困难、部位特殊或需要联合脏器切除的原发局限性GIST．术前伊马替尼治疗可以使肿瘤降期而降低手术风险．提高切除率．甚至保留脏器功能。而对于进展期GIST，靶向药物是治疗的首选，外科手术干预尽管在一些回顾性的病例分析中显示出一定的效果．但仍缺乏前瞻性对照试验的证据支持。如何在两类患者中更好地结合靶向治疗和外科手术已成为GIST综合治疗实施的关键。
For primary localized gastrointestinal stromal tumor （GIST）, complete resection followed by imatinib adjuvant therapy has become a consensus among physicians for median and high risk patients. Preoperative imatinib may decrease surgical morbidity, increase resection rate, and even preserve organ function through down-staging of the tumor. For advanced GIST, the choice of treatment is targeted therapy with tyrosine kinase inhibitor. Although surgical intervention showed certain efficacy in several retrospective analyses, the role of surgery for advanced disease still needs to be proven by prospective controlled trials. Better combination of targeted therapy and surgery has become critical in muhidisciplinary therapy for GIST.
出处
《中华胃肠外科杂志》
CAS
2012年第3期201-203,共3页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肠间质瘤
靶向治疗
外科手术
Gastrointestinal stromal tumors
Targetedtherapy
Surgical procedures
