强直性脊柱炎病情活动度评分对强直性脊柱炎患者病情活动性判断的价值被引量：56

The value of ankylosing spondylitis disease activity score in evaluating disease activity of ankylosing spondylitis

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摘要目的评价强直性脊柱炎病情活动度评分（ASDAS）在判断强直性脊柱炎（AS）患者病情活动度时的价值。方法采用ASDAS、强直性脊柱炎病情活动指数（BASDAI）对AS患者的病情活动度进行评价，以患者总体评价、医生总体评价、患者是否需要强化治疗决策作为评价疾病活动度的标准。目前常用的计算ASDAS有2种，一种是基于C反应蛋白（CRP）计算的ASDAS（ASDAS．CRP），一种是基于ESR计算的ASDAS（ASDAS．ESR）。结果227例AS患者人选本研究。BASDAI、ASDAS-ESR、ASDAS-CRP与患者总体评价有较好的相关性（r值分别为0．713、0．698、0．725，P：0．000）。BASDAI、ASDAS．ESR、ASDAS-CRP与医生总体评价有较好的相关性（r值分别为0．771、0．782、0．847，P=0．000）。ASDAS-CRP与病情活动度的相关程度优于BASDAI。ASDAS-CRP判断AS病情活动度的准确性最高（AUC为0．849），其次为ASDAS．ESR（AUC为0．845），最差是BASDAI（AUC为0．832），ASDAS比BASDAI能更好地反映疾病活动度。结论ASDAS是一种较理想的评价AS病情活动度的指标。 Objective To investigate the value of ankylosing spondylitis （AS） disease activity score （ASDAS） and the Bath AS disease activity index （BASDAI） in evaluating disease activity in AS. Methods ASDAS and BASDAI were used to evaluate disease activity in patients with AS, taking the patients＇ global scores, physician global scores and treatment decision as the ＂gold standard＂ for disease activity. According to the ＂ gold standard＂, the patients were divided into low and high disease activity groups. Statistical analysis included descriptive statistics, linear correlation and regression and ROC curve. Results A total of 227 patients with AS were included. ASDAS and BASDAI showed good correlation with disease activity as reflected by the patients＇ global score [ r for BASDAI, ASDAS based on ESR（ASDAS-ESR） and ASDAS based on C-reactive protein（ASDAS-CRP） were O. 713, 0. 698 and 0. 725, respectively, P = 0. 000] and the physician global score （ r for BASDAI, ASDAS-ESR and ASDAS-CRP were 0. 771, 0. 782, 0. 847, respectively, P = 0. 000）. Both scores showed good discriminative ability for high and low disease activity states. ASDAS-CRP had the highest sensitivity. Conclusion ASDAS is a promising tool for evaluating disease activity in AS oatients.

作者杜旭娜李晏张胜利朱剑黄烽

机构地区解放军总医院风湿科

出处《中华内科杂志》 CAS CSCD 北大核心 2012年第3期206-209,共4页 Chinese Journal of Internal Medicine

关键词脊柱炎强直性病情活动度强直性脊柱炎病情活动度评分强直性脊柱炎病情活动指数 Spondylitis, ankylosing Disease activity Ankylosing spondylitis disease activityscore Bath ankylosing spondylitis disease activity index

分类号 R593.23 [医药卫生—内科学]

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