摘要
目的 探讨血浆生长抑素含量在小儿原发性肠套叠发病及病理发展中的变化和作用。方法 采用放射免疫测定法，测定４１ 例原发性肠套叠患儿血浆生长抑素含量值，并与６０ 例正常儿和１２ 例肠梗阻患儿进行比较。结果 血浆生长抑素含量在生后３ 个月达到峰值，之后逐渐下降。肠套叠组血浆生长抑素量在灌肠组、麻醉组、手术组依次升高，灌肠组平均值低于正常对照组，麻醉组和手术组均高于正常对照组，肠梗阻组血浆生长抑素含量则明显高于其他各组。结论 原发性肠套叠发病及病理发展过程中存在血浆生长抑素含量的规律性变化，其含量可作为判定肠套叠病理变化程度的指标，此变化可能在肠套叠发病及病理发展过程中起一定作用，并从理论上提出生长抑素类似物应用于肠套叠辅助治疗的可行性。
Objective To study the levels of plasma somatostatin throughout the course of intussusception.Methods Post prandial plasma somatostatin concentrations were measured with radioimmunoassay in 41 patients with intussusception, 12 patients with intestinal obstruction and 60 normal controls. Patients with intussusception were subdivided into air reduction, anaesthetic and operative groups. Results In the normal control group, the plasma somatostatin level peaked at 3 months of age and declined thereafter. The plasma somatostatin was lowest in the air reduction group, higher in the anaesthetic group and highest in the operative group. The plasma somatostatin level of the former group was significantly lower than that of the controls whereas the levels of the latter two groups were higher than that of the controls. The highest level was recorded in patients with intestinal obstruction.Conclusions Plasma somatostatin is implicated in the process of intussusception and can be used as a marker of the process. Somatostatin analogue may be potentially useful in non operative management of intussusception.
出处
《中华小儿外科杂志》
CSCD
2000年第1期40-42,共3页
Chinese Journal of Pediatric Surgery
关键词
生长抑素
肠套叠
放射免疫测定
Somatostatin
Intussusception
Radioimmunoassay
