摘要
目的探讨急性脑血管病患者血浆组织型纤溶酶原激活物(tissue-type plasminogen activator,t-PA)及纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor-1,PAI-)抗原含量的变化规律。方法运用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)法测定2007年10月至2008年9月78例急性脑出血、脑梗死和短暂性脑缺血发作(transient ischemic attack,TIA)患者血浆t-PA及PAI-1抗原含量水平,并与同期22例健康对照组进行比较。结果 5对照组比较,脑出血组血浆t-PA水平明显升高、PAI-1水平降低(P均<0.001);脑梗死组血浆t-PA及PAI-1水平均较对照组明显升高(P均<0.001);TIA组血浆t-PA水平低于对照组(P=0.006),PAI-1水平升高(P<0.001)。结论急性脑血管病患者存在纤溶活性的异常。
Objective To explore the change of some factors tissue-type plasminogen activator（t-PA） and plasminogen activator inhibitor-l（PAl-1） in the patients with acute cerebrovascular disease and to provide some theorical evidences for the clinical treatment.
Methods The level of t-PA, PAl-1 antigen in the 78 patients with acute cerebral hemorrhage, cerebral infarction and transient ischemic attack（TIA） was determined by enzyme-linked immunosorbnent assay（ELISA） from October 2007 to September 2008. These data were compared with control group, which contains 22 patients.
Results To the cerebral hemorrhage, the level of t-PA of experimental group was higher than those of the control group（P〈0.001）. The level of PAP! antigen was lower than those of the control group（P〈0.001）. The differences between the experimental group and the control group were significant. To the cerebral infarction, the level of t-PA and PAI-I antigen of experimental group was higher than those of the control group（P〈0.001）. In TIA, the level of PAI-1 antigen in experimental group was higher than those in control group（P〈0.001）. The level of t-PA was lower（P=0.006）. The differences between the experimental group and the control group were significant（P〈0.001）.
Conclusion To the patients with acute cerebrovascular diseases, there is disturbance of blood coagulation, anticoagulation and fibrolysis.
出处
《中国卒中杂志》
2012年第3期197-201,共5页
Chinese Journal of Stroke
关键词
急性脑血管病
脑出血
脑梗死
短暂性脑缺血发作
凝血
纤溶
Acute cerebrovascular disease
Cerebral hemorrhage
Cerebral infarction
Transient ischemic attack
Coagulation
Fibrolysis
