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慢性心力衰竭患者血清生长分化因子-15、脑利钠肽水平与心功能状态的关系 被引量：5

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摘要 目的研究慢性心力衰竭(CHF)患者血清生长分化因子-15(GDF-15)、脑利钠肽(BNP)水平的变化及其与心脏功能的关系。方法以CHF患者48例作为研究对象,根据NYHA标准分级,心功能Ⅱ级13例,心功能Ⅲ级19例、心功能Ⅳ级16例。采用酶联免疫吸附试验(ELISA法)测定血清GDF-15水平、BNP水平。并以48例健康自愿者作为对照组进行比较研究。结果 CHF组血清GDF-15、BNP水平较对照组均显著增高(P<0.01),并且随着NYHA心功能分级的增高而逐渐升高。血清GDF-15水平、BNP水平均与LVEF呈负相关(r=-0.543,r=-0.576,P<0.001),而且GDF-15与BNP之间呈正相关(r=0.558,P<0.001)。结论在CHF患者中,GDF-15与BNP均可反映心衰的严重程度,其中GDF-15水平更为敏感;血清GDF-15与BNP不仅可以反映心脏功能状态,而且两者在CHF的病理生理过程中有一种相互影响的关系。
作者 武德梅 张龙 陈超 张明 刘袁颖
机构地区 中国石油中心医院保健中心 中国石油中心医院检验科 中国石油中心医院肾内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第6期1159-1160,共2页 Chinese Journal of Gerontology
关键词 慢性心力衰竭 生长分化因子-15 脑利钠肽
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献16

  • 1Brown DA,Breit SN,Buring J,et al.Concentration in plasma of macro-phage inhibitory cytokine-1 and risk of cardiovascular events in women:a nested case-control study(J).Lancet,2002;359(9324):2159-63.
  • 2Tan M,Wang Y,Guan K,et al.PTGF-beta,a type beta transforming growth factor(TGF-beta)superfamily member,is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway(J).Proc Natl Acad Sci USA,2000;97(1):109-14.
  • 3Kempf T,Eden M,Strelau J,et al.The transforming growth factor-βsu-perfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury(J).Circ Res,2006;98(3):351-60.
  • 4Xu J,Kimball TR,Lorenz JN,et al.GDF15/MIC-1 functions as a protec-tive and antihypertrophic factor released from the myocardium in associa-tion with SMAD protein activation(J).Circ Res,2006;98(3):342-50.
  • 5Maeda K,Tsutamoto T,Wada A,et al.Plasma brain natricuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction(J).Am Heart J,1998;135(5-1):825-32.
  • 6Levin ER,Gardner DG,Samson WK,et al.Natriuretic peptides(J).N Engl J Med,1998;339(5):321-7.
  • 7Cargill RI,Barr CS,Coutie WJ,et al.C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure(J).Thorax,1994;49(12):1247-9.
  • 8Yoshimura M,Yasue H,Okumura K,et al.Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure(J).Circulation,1993;87(2):464-9.
  • 9Lind L,Wallentin L,Kempf T,et al.Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the eld-erly:results from the Prospective Investigation of the Vasculature in Upp-sala Seniors(PIVUS)Study(J).Eur Heart J,2009;30(19):2346-53.
  • 10Kempf T,von Haehling S,Peter T,et al.Prognostic utility of growth dif-ferentiation factor-15 in patients with chronic heart failure(J).J Am Coll Cardiol,2007;50(11):1054-60.

同被引文献45

  • 1张莹莹,吕晓红,丁会.老年慢性肺源性心脏病心力衰竭急性加重期患者血清降钙素原与B型利钠肽水平变化[J].中国老年学杂志,2014,34(7):1746-1747. 被引量：30
  • 2杨璇,李玉,李长江,冯磊.GDF-15与心肌梗死后心室重塑指标的相关性[J].中国老年学杂志,2015,35(1):59-60. 被引量：12
  • 3杨永健,张鑫,孙梅芹.血管紧张素Ⅱ受体拮抗剂对心肌重构的保护机制[J].临床心血管病杂志,2005,21(11):663-665. 被引量：2
  • 4王晓健,惠汝太.一个新的保护心脏TGF-β超家族成员——GDF15[J].中国分子心脏病学杂志,2006,6(4):242-245. 被引量：5
  • 5张利群,贾志梅,王洪涛,汪薇.缬沙坦对大鼠心肌梗死后心室重构的影响[J].中国医科大学学报,2007,36(1):57-58. 被引量：3
  • 6Hunt SA,Abraham WT,Chin MH,et al.ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines(Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure):developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation:endorsed by the Heart Rhythm Society[J].Circulation,2005,112(12):e154-e235.
  • 7Dickstein K,Cohen-Solal A,Filippatos G,et al.ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008:the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association of the ESC(HFA)and endorsed by the European Society of Intensive Care Medicine(ESICM)[J].Eur Heart J,2008,29(19):2388-2442.
  • 8Dinh W,Füth R,Lankisch M,et al.Growth-differentiation factor-15:a novel biomarker in patients with diastolic dysfunction?[J].Arq Bras Cardiol,2011,97(1):65-75.
  • 9Bootcov MR,Bauskin AR,Valenzuela SM,et al.MIC-1,a novel macrophage inhibitory cytokine,is a divergent member of the TGF-beta superfamily[J].Proc Natl Acad Sci U S A,1997,94(21):11514-11519.
  • 10Wollert KC,Kempf T.Growth differentiation factor 15 in heart failure:an update[J].Curr Heart Fail Rep,2012,9(4):337-345.

引证文献5

二级引证文献46

中国老年学杂志
2012年 第6期

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