摘要
α-糖苷酶抑制剂其结构类似于糖,可以竞争性的与α-糖苷酶结合,减少寡糖水解成单糖,从而降低餐后血糖浓度,对糖尿病患者具有治疗作用。本文概述了天然产物来源的糖苷酶抑制剂这类化合物的应用、作用机制、来源植物、结构特点、生物活性,提取分离方法、及其主要活性成分DNJ的分析方法。
α-glucosidase inhibitors, of which the structures are similar to oligosaccharides, could competitively inhibit α- glucosidase and prevent disaccharides hydrolyzing into monosaccharides. Therefore,the peak blood sugar concentration after meal was significantly decreased by using theα-glucosidase inhibitors, a-glucosidase inhibitors have therapeutic function on diabetes. In this paper, the mechanisms, original plants, structures, bioactivities, extraction and separation methods of a-glucosidase inhibitors from natural products, as well as the analytical approach of bioactive component DNJ were introduced and summarized.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2012年第3期414-420,共7页
Natural Product Research and Development
基金
广东省教育部产学研项目(2009B090600117)
