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肉毒碱棕榈酰转移酶-1活性对饱和脂肪酸诱导乳鼠心肌细胞凋亡的影响 被引量：1

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摘要 目的:观察肉毒碱棕榈酰转移酶-1(CPT-1)的活性变化在饱和脂肪酸致乳鼠心肌细胞凋亡过程中的作用。方法:应用饱和脂肪酸棕榈酸盐(palmitate)处理乳鼠心肌细胞,使用CPT-1抑制剂(perhexiline)和CPT-1辅助因子左旋肉碱(L-carnitine)进行干预,采用流式细胞术观察心肌细胞凋亡变化情况。结果:palmitate组的细胞凋亡率较对照组(0.19±0.03vs0.07±0.02,P<0.01)及L-carnitine处理组(0.19±0.03vs0.14±0.02,P<0.01)显著升高,较perhexiline处理组(0.19±0.03vs0.29±0.03,P<0.01)显著下降。结论:心肌细胞对脂肪酸利用能力下降在palmitate诱导心肌细胞凋亡过程中具有重要意义。
作者 张治宇 袁志忠 殷仁富 徐丽萍
机构地区 第二军医大学长征医院贵宾诊疗科
出处 《实用医学杂志》 CAS 北大核心 2012年第6期902-904,共3页 The Journal of Practical Medicine
关键词 心肌细胞 饱和脂肪酸 细胞凋亡 大鼠
分类号 R965 [医药卫生—药理学]
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参考文献6

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共引文献6

同被引文献11

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实用医学杂志
2012年 第6期

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