摘要
对于具有较强血管刺激性的药物,使用合理的刺激性评价指标,筛选出合适的制剂处方,以降低其血管刺激性,对于提高注射剂临床用药安全性和患者顺应性具有重要意义。本文从静脉给药导致血管刺激性的机制出发,综述了处方筛选中注射剂血管刺激性的评价体系,以期为研制刺激性小、耐受性好的注射剂提供参考。
Screening proper injection preparations of strong irritant drugs with reasonable evaluation methods to decrease the venous irritation has an important effect on improving drug security and patient compliance. In this paper, the mechanism of venous irritation is introduced and different evaluation systems on venous irritation for injection are summarized. The aim of this paper is to provide references for preparing injection with low irritation and good compliance.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第3期222-226,共5页
Chinese Journal of Pharmaceuticals
基金
国家“重大新药创制”科技重大专项(2009ZX09301-007)
关键词
血管刺激性
注射剂
处方筛选
综述
venous irritation
injection
formulation screening
review
