摘要
目的:评估老年冠心病患者超敏肌钙蛋白T(hs-TnT)轻度升高的临床意义,并探讨其可能机制。方法:入选年龄>70岁患者250例,均留取入院次日晨起空腹静脉血,住院期间完成冠状动脉造影,并明确诊断为冠心病;依据hs-TnT值分为轻度升高组(0.014～0.100μg/L)和正常组(<0.014μg/L)。结果:2组患者冠状动脉病变严重程度、左室重量指数[(90.0±26.1)g/m2∶(100.0±30.9)g/m2]、左室收缩功能[(56.0±6.7)%∶(50.0±7.9)%]、估测肾小球滤过率{[(66(74～52)]ml/(min.1.73m2)∶[60(70～49)]ml/(min.1.73m2)}比较均差异有统计学意义(均P<0.05);2组炎症反应指标、左室舒张功能差异无统计学意义。结论:hs-TnT轻度升高与老年冠心病患者冠状动脉病变严重程度、左室重量指数增加、左室收缩功能下降、肾功能减退相关,可作为老年冠心病早期危险分层的一个指标并能指导临床治疗。
Objective：To assess the low level high sensitive troponin T（hs-TnT） in patients with elderly coronary heart dieases,and detect the pathophysiological mechanisms. Method：Two hundred and fifty patients over 70 years old with coronary heart disease were selected.All patients were completed coronary angiography during hospital stays,then divided into normal group（〈0.014 μg/L） and low level elevated group（0.014～0.100 μg/L） according hs-TnT level. Result：There were significant differences in the severity of coronary artery disease,left ventricular mass index,left ventricular systolic function,estimated glomerular filtration rate between 2 groups,while no difference in inflammatory response index and left ventricular diastolic function. Conclusion：Low level elevation of hs-TnT associated with the severity of coronary artery disease,left-ventricula mass index,impaired left-ventricular systolic function and impaired renal function.Hs-TnT may be a clinical indicator for high cardiovascular risk in patients with elderly coronary heart disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第3期206-208,共3页
Journal of Clinical Cardiology
基金
浦东新区科技发展基金资助项目(No:pkj2010
Y34)
关键词
冠心病
老年
超敏肌钙蛋白T
coronary heart dieases
elderly
high sensitive troponin T
