摘要
目的观察消癥汤治疗子宫肌瘤的临床疗效。方法将260例患者随机分为治疗组和对照组,每组130例,治疗组服用消癥汤,每日1剂分2次服,对照组口服米非司酮每日1次25mg,两组均治疗3个月并进行1年后随访。观察治疗前后及1年后子宫及子宫肌瘤大小,同时观察肌瘤大小对疗效的影响;并于治疗前后对患者进行焦虑程度(SAS)评分及血红蛋白水平测定。结果治疗后两组患者子宫及子宫肌瘤大小均较治疗前明显减小(P<0.05),1年后随访治疗组患者子宫及子宫肌瘤大小明显小于对照组(P<0.05);治疗后两组均能减小最大子宫肌瘤直径(P<0.05),1年后治疗组最大子宫肌瘤直径均明显低于对照组(P<0.05);治疗组治疗后患者的SAS评分降低、血红蛋白水平升高(P<0.05或P<0.01);治疗组治疗后SAS评分、血红蛋白水平与对照组比较差异有统计学意义(P<0.05或P<0.01)。治疗组总有效率86.92%,对照组总有效率75.38%,治疗组患者临床疗效优于对照组(P<0.05)。结论消癥汤和米非司酮均有较好的缩小子宫和子宫肌瘤的作用,但在消除焦虑、改善贫血方面消癥汤优于米非司酮,且治疗后子宫肌瘤复发率低于米非司酮。
Objective To observe the therapeutic effect of terine leiomyoma. Methods 260 patients were randomized Xiaozheng Decoction （decoction for dispersing concretions） tor u- into treatment group and control group, with 130 in each. The treatment group was given Xiaozheng Decoction, twice daily. The control group was given mifepristone, 25mg per time, once daily. Both groups were treated for 3 months and followed up for 1 year. The sizes of uterus and uterine leiomyoma were ob- served at the beginning and ending of the treatment and after one year＇s follow-up. The relationship between leomyoma size and therapeutic effect was observed as well. The Self-Rating Anxiety Scale （SAS） was used to score and hemoglobin was detected. Results The uterus and uterine leiomyoma minished significantly in both groups after treatment （P〈0.05）. After one year＇s follow-up, the size of uterus and uterine leiomyoma in the treatment group was significantly smaller than that in the control group （P〈0.05）. After treatment, the diameter of the largest leiomyoma was significantly shorter than that before treatment in both groups （P〈0. 05）. After one year＇s follow-up, the diameter of the largest leiomyoma in the treatment group was signif- icantly shorter than that in the control group （P〈0.05）. The SAS score decreased and the content of hemoglobin increased significantly in the treatment group （P〈0.05 or P〈0.01）, with significant difference between groups （P〈0.05 or P〈 0.01）. The total effective rate of the treatment group and control group was 86.92% and 75.38% respectively, with signifi- cant difference （P〈0.05）. Conclusion leiomyoma. Xiaozheng Decoction has a as compared with mifepristone. Both Xiaozheng Decoction and mifepristone could reduce the size of uterus and uterine better effect in eliminating anxiety and improving anaemia with lower recrudescence rate as compared with mifepristone.
出处
《中医杂志》
CSCD
北大核心
2012年第7期588-590,594,共4页
Journal of Traditional Chinese Medicine
基金
温州市2010年度医药卫生科学研究项目计划资助项目(2010A011)
关键词
消癥汤
子宫肌瘤
米非司酮
焦虑程度评分
血红蛋白
Xiaozheng Decoction （decoction for dispersing concretions）
uterine leiomyoma
mifepristone
Self-Rating Anxiety Scale
hemoglobin
