摘要
各种类型的终末期肝病严重威胁着人类的健康。现有的常规治疗方法均不理想，原位肝移植亦因供体肝的短缺受到限制，而以肝干细胞移植为基础的新型疗法则具有光明前景。肝卵圆细胞是受损肝脏内的一种肝干／祖细胞，或称肝前体细胞。由于其细胞核呈卵圆形，核质比高等形态学特征，故而得名。经过几十年的探索，肝卵圆细胞研究已经获得了初步的成果。现在人们已将注意力逐渐转移到肝卵圆细胞激活、分化的调控机制方面，而调控机制中的信号通路又是研究的重点。肝卵圆细胞的激活和增殖过程有许多信号通路参与。Wnt／β-catenin信号通路作为Wnt信号通路的一个分支，对肝卵圆细胞的激活和增殖有重要作用，但其具体机制尚未阐明。本文就肝卵圆细胞激活和增殖过程中Wnt／β-catenin信号通路的作用做一综述。
End-stage liver disease is a serious threat to human health. Existing conventional therapies are far from ideal, and orthotopic liver transplantation is limited by the lack of donor liver. A new therapy, transplantation of hepatic stem cell, is a promising approach. Hepatic oval cells are hepatic stem/progenitor cells （HSC/HPC） during hepatic regeneration, and they are being referred to as hepat- ic precursor cells. It got its name because of its oval nucleus, high nuclear/cytoplasmic ratio and other morphological fea- tures. Research has shown increasingly importance in the knowledge of hepatic oval cells. There are many signaling pathways in hepatic oval cells activation and proliferation. As a branch of the Wnt signaling pathway, Wnt/β-catenin signaling pathway has a significant effect on hepatic oval cells activation and proliferation. However, the exact mechanisms of this process have not been completely elucidated. This review describes the role of Wnt/β-catenin signaling pathway in hepatic oval cell activation and proliferation.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2012年第3期235-238,共4页
Chinese Journal of Hepatobiliary Surgery
基金
基金项目：广东省自然科学基金（04004534）
广东省科技计划项目（20098030801371）
