摘要
目的探讨自体角膜缘干细胞移植治疗较小角膜皮样瘤的可行性。方法前瞻性研究。将34例角膜皮样瘤患者按完全随机对照方法分成A组（肿瘤切除联合自体角膜缘干细胞移植术）；B组（肿瘤切除联合异体板层角膜移植术）。观察患者术后经过、肿瘤复发、以及视力、屈光度、散光度等情况。结果A、B两组术后均未出现肿瘤复发，治愈率100％。A、B两组术后早期均有不同程度的角膜上皮糜烂，1月后角膜上皮基本愈合。A组2年后遗留不同程度的角膜翳，但未见新生血管进入角膜；B组术后外观改善良好，13例患者移植片透明。术后早期2例患者出现轻度层间混浊，新生血管到达角膜缘，3例患者出现层间新生血管，这5只眼治疗后，移植片透明。A、B两组术后裸眼视力、最佳矫正视力、屈光度、散光度差异无统计学意义（P〉0．05）。结论肿瘤切除联合自体角膜缘干细胞移植术对较小的角膜皮样瘤的疗效等同于异体板层角膜移植术，且该术式取材方便，手术简单，是一种安全可行的治疗方法。
Objective To discuss the feasibility analysis of tumor excision along with limbal stem cell transplantation for smaller range of corneal dermoid tumor. Methods Prospective study： The 34 corneal dermoid patients whom met the criteria were randomly divided into control group A （took limbal stern cell transplantation） and group B （took allogeneic lamellar keratoplasty）. After-wards, patients＇ visual acuity, dioptre, cylinder and other indicators of clinical efficacy were observed. Results Group A and B had no significant difference in efficacy of best corrected visual acuity dioptre and cylinder. And both group A and B had no significant complications. Conclusions The efficacy of resection combined with autologous limbal stem cell transplantation for the smaller range of corneal dermoid are equal to the allogeneic lamellar keratoplasty, but the former is simpler in operation and has very few medical rejection. Its postoperative medication is also simple. Therefore,it is a safe and feasible surgical method.
出处
《中国实用眼科杂志》
CSCD
北大核心
2012年第3期288-291,共4页
Chinese Journal of Practical Ophthalmology
关键词
角膜皮样瘤
移植
角膜缘干细胞
Corneal dermoid
Transplantation
Corneal limbal stem cells
