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子宫体恶性血管周上皮样细胞肿瘤1例并文献复习 被引量：12

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摘要 目的探讨子宫体恶性血管周上皮样细胞肿瘤(perivascular epithelioid cell tumors,PEComa)的临床病理学特征、诊断及鉴别诊断。方法采用免疫组化SP法对1例子宫体恶性PEComa进行免疫组化标记并复习相关文献。结果患者扪及下腹部巨大肿块6个月,手术切除后11个月复发,CT示中下腹一巨大低-高密度混杂肿块。眼观:原发和术后复发肿瘤均体积巨大,切面为灰黄、灰红色,边界不清,质脆伴坏死。镜检:瘤细胞呈上皮样,胞质嗜酸性至透明,细胞异型性明显,可见明显核仁,未见核分裂。免疫组化:vimentin、HMB-45和Melan-A均(),PNL2(),Ki-67增殖指数约3%,EMA、CK(AE1/AE3)、S-100、CD10、desmin、SMA和MSA均(-)。结论子宫体恶性PEComa十分罕见,需与子宫体恶性黑色素瘤、上皮样平滑肌肿瘤和横纹肌肉瘤相鉴别。
作者 伍健 李媛 贺玉洁
机构地区 上海市浦东新区公利医院病理科 复旦大学肿瘤医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2012年第3期333-336,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 子宫体肿瘤 血管周上皮样细胞肿瘤 恶性
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Bonetti F,Pea M,Martignoni G,et al.PEC and sugar[J].Am J Surg Pathol,1992,16(3):307-8.
  • 2Zamboni G,Pea M,Martignoni G,et al.Clear cell "sugar" tumor of the pancreas.A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells[J].Am J Surg Pathol,1996,20(6):722-30.
  • 3Ciarallo A,Makis W,Hickeson M,et al.Malignant perivascular epithelioid cell tumor (PEComa) of the uterus:serial imaging with F-18 FDG PET/CT for surveillance of recurrence and evaluation of response to therapy[J].Clin Nucl Med,2011,36(4):e16-9.
  • 4Liu J L,Lin Y M,Lin M C,et al.Perivascular epithelioid cell tumor (PEComa) of the uterus with aggressive behavior at presentation[J].Hematol Oncol Stem Cell Ther,2009,2(3):426-30.
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  • 6Folpe A L,Mentzel T,Lehr H A,et al.Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin:a clinicopathologic study of 26 cases and review of the literature[J].Am J Surg Pathol,2005,29(12):1558-75.
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同被引文献107

  • 1Wolfgang Scheppach,Nikolaus Reissmann,Thomas Sprinz,Ekkehard Schippers,Bjoern Schoettker,Justus G Mueller.PEComa of the colon resistant to sirolimus but responsive to doxorubicin/ifosfamide[J].World Journal of Gastroenterology,2013,19(10):1657-1660. 被引量：11
  • 2王占东,王小玲.血管周上皮样细胞分化肿瘤的研究进展[J].临床与实验病理学杂志,2005,21(1):115-116. 被引量：10
  • 3赖日权,冯晓冬,胡维维,王卓才.具有上皮样细胞形态软组织肿瘤的诊断与鉴别诊断[J].诊断病理学杂志,2005,12(4):241-244. 被引量：5
  • 4杨幼萍,朱扬丽,武卫平,王照明,张建民.子宫血管周上皮样细胞肿瘤临床病理观察[J].中华病理学杂志,2007,36(5):302-306. 被引量：12
  • 5王坚,朱雄增.软组织肿瘤病理学[M].北京:人民卫生出版社.2008:81-84,124-126.
  • 6Folpe AL, Mentzel T, Lehr HA, et al. Perivascular epithelioid cell neaplasmas of soft tissue and gynecologic origin, a clinicopatho- logic study of 26 cases and review of the literature[J]. Am J Surg Pathol,2005,29(12) : 1558.
  • 7Bonetti F, PeaM, Mattignoni G, et al. PEC and sugar[J]. Am J Surg Pathol, 1992,16(3) : 307.
  • 8Zamboni G, PeaM, Martignoni G, et al. Clear cell"sugar"tumor of panerceas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cell[J]. Am J Surg Pathol,1996,20(6):722.
  • 9Fletcher CDM, Unnikk, M ertens F. World Health Organization classification of tumours of soft tissue and bone[M]. Lyon IARC Press 2002,221.
  • 10Van slegtenhorst M,de Hoogt R, H eimans C, et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34[J].Sci- ence, 1997,227(5237) :85.

引证文献12

二级引证文献27

临床与实验病理学杂志
2012年 第3期

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