摘要
目的调查新乡医学院第二附属医院精神科门诊患者2011年3月7日精神药物的使用现况。方法当日精神科门诊330例患者,对其主要使用的抗精神病药、抗抑郁药、心境稳定剂、镇静催眠药/抗焦虑药物治疗处方进行调查。结果①当日330例精神科门诊患者中,男性152例(46.1%),女性178例(53.9%),临床诊断主要为精神分裂症、抑郁症、双相障碍、躁狂、神经症(包括强迫症、抑郁症、躯体形式障碍)、脑器质性障碍、睡眠障碍、焦虑等。②330例患者中使用1种精神药物的108例(32.7%),使用多种精神药物的212例(64.2%),应用辅助药物的9例(2.7%),抗精神病药使用频率居前5位的是氯氮平和利培酮各35例(10.6%)、阿立哌唑28例(8.5%)、舒必利26例(7.9%)、喹硫平24例(7.3%),齐拉西酮16例(4.8%)。抗抑郁药使用频率居前5位的是舍曲林33例(10.0%),帕罗西汀20例(6.1%),米氮平、曲唑酮、氟西汀和氟伏沙明各14例(4.2%),文拉法辛和米安色林各10例(3.0%),瑞波西汀4例(1.2%)。使用心境稳定剂居前5位的是丙戊酸镁14例(4.2%)、碳酸锂9例(2.7%)、丙戊酸钠8例(2.4%)、奥卡西平5例(1.5%)、拉莫三嗪4例(1.2%)。使用镇静催眠药/抗焦虑药居前5位的是:氯硝西泮42例(12.7%)、阿普唑仑36例(10.9%)、劳拉西泮24例(7.3%)、丁螺环酮22例(6.7%)、佐匹克隆19例(5.8%)。结论新型非典型抗精神病药和抗抑郁药已经成为精神分裂症和抑郁症治疗的主要药物,多种精神药物的联用较多,反应出精神药物治疗精神疾病处方模式的发展趋势。
Objective To investigate psychotropics use in out-patient clinics of psychiatry, the Second Affiliated Hospital of Xinxiang Medical College on March 7, 2011. Methods A survey in a total of 328 patients in psychiatric clinics was undertaken to determine the use of psychotropics, including antipsychotics, antidepressants, mood stabilizers and hypnotics/anxiolytics. Results Of 330 patients surveyed （152 males and 178 females）, the most common clinical diagnoses were schizophrenia, depression, bipolar disorders, mania, compulsive disorder, neurosis, cerebral disorder, insomnia and anxiety. Of 330 patients, 108 （32.7%） were treated with monotherapy, 212 （64.2%） received multiple medications and 9 （2.7%） were on adjunct medications. The most frequently prescribed antipsychotics were clozapine （35 cases, 10.6 %）, risperidone （35 cases, 10.6 %）, aripiprazole （28 cases, 8.5%）, sulpiride （26 cases, 7.9%）, quetiapine （24 cases, 7.3%） and ziprasidone （16 cases, 4.8%）. And the most commonly prescribed antidepres- sants were sertraline （33 cases, 10.0%）, paroxetine （20 cases, 6.1%）, mirtazapine （14 cases, 4.2%）, trazodone （14 cases, 4.2%）, fluoxetine （14 cases, 4.2%）, fluvoxamine （14 cases, 4.2%）, venlafaxine （10 cases, 3.0%）, mianserin （10 cases, 3.0%） and reboxetine （4 cases, 1.2%）. Mood stabilizers in most frequent use was magnesium valproate （14 cases, d.2%）, lithium carbonate （9 cases, 2.7%）, sodium valproate （8 cases, 2.4%）, oxacarbazepine （5 cases, 1.5%） and lamotrigine （4 cases, 1.2%）. The five frequently prescribed hypnotics/anxiolytics were clonazepam （42 cases, 12.7%）, alprazolam （36 cases, 10.9 %）, lorazepam （24 cases, 7.3%）, buspirone （22 cases, 6.7%） and zopiclone （19 cases, 5.8%）. Conclusion The novel atypical antipsychotics and antidepressants have become the mainstay for schizophrenia and depression therapy. Common application of multiple medications it is indicative of the development trend in psychotropics prescription.
出处
《中国药物与临床》
CAS
2012年第3期290-293,共4页
Chinese Remedies & Clinics
基金
河南省卫生科技创新型人才工程专项(2011-2015)
关键词
抗精神病药
抗抑郁药
心境稳定剂
镇静药和催眠药
抗焦虑药
处方
Antipsychotic agents
Antidepressive agents
Mood stabilizers
Sedatives and hypnotics
Anxiolytics
Prescriptions
