摘要
以二甲基肼诱发Wistar大鼠大肠癌为模型,研究了绿茶和茶色素(红茶的主要成分)大肠癌的化学预防作用和对大肠肿瘤的影响。结果表明,在第16周2个饮茶组动物的变性隐窝病灶(ACF)形成数比阳性对照组显著减少(P< 0.01);在第32周时阳性对照组100% 发生了肿瘤(平均瘤数为2.6个/只,平均瘤体积为294.7m m 3/瘤)。绿茶组和茶色素组的平均瘤数抑制率分别为47.1% 和43.1% ,平均瘤体积抑制率分别为77.1% 和68.1% 。表明绿茶和茶色素对实验性大肠肿瘤具有预防作用。
The present study was designed to investigate the chemopreventive effects of green tea and tea pigments(the main component of black tea)on 1,2 dimethylhydrazine(DMH) induced rat colorectal carcinogenesis.Compared with the positive control group,green tea and tea pigments groups had less numbers of aberrant crypt foci(ACF)( P <0 01)at the end of week 16.At the end of week 32,all rats in the positive control group developed colorectal tumors with an average of 2 6 tumors per rat,and a mean volume of 294 7mm 3 per tumor,while in the groups drinking green tea and tea pigments,the average numbers of colorectal tumors per rat were only 47 1% and 43 1% of controls respectively,and the mean tumor volume was inhibited by 77 1% and 68 1% respectively.It was concluded that tea pigments had a chemopreventive effect on colorectal tumor and ACF formation can be used as a useful intermediate end point to study chemopreventive effects on colorectal cancer.
出处
《卫生研究》
CAS
CSCD
北大核心
2000年第1期54-56,共3页
Journal of Hygiene Research
