经皮冠状动脉介入治疗对急性心肌梗死患者氨基末端脑钠肽前体水平及预后的影响被引量：22

THE EFFECTS OF PERCUTANEOUS CORONARY INTERVENTION ON LEVEL OF N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE AND PROGNOSIS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

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摘要目的研究急性心肌梗死(AMI)患者接受急诊或择期经皮冠状动脉介入治疗(PCI)后血浆氨基末端脑钠肽前体(NT-proBNP)变化及其与心功能、心血管事件的关系。方法 2009年7月～2010年12月,发病后12 h内接受急诊PCI治疗的ST段抬高AMI患者为A组(n=46例),住院期间行择期PCI治疗者为B组(n=42),发病后24小时内入院的AMI患者未行再灌注治疗者为C组(n=34);测量NT-proBNP,完善心脏彩超检查,记录三组患者半年内的心血管事件。结果 A组NT-proBNP在入院后较B、C组明显下降,B组NT-proBNP在心肌梗死第11天及以后较C组明显下降;心功能方面:A、B组,A、C组及B、C组在第45天及半年时差异明显;A、B、C三组心血管事件组间差异明显;上述差异有统计学意义(p<0.05)。结论AMI患者行急诊或择期PCI后NT-proBNP明显下降,能降低心血管事件,但急诊PCI优于择期PCI治疗;同时NT-proBNP水平可作为患者心功能预测因子。 Objective To explore the change of N-Terminal Pro-Brain natriuretic peptide（NT-proBNP） value in acute myocardial infarction（AMI） patients after emergent or selective percutaneous coronary intervention（PCI） treatment and its relationship with cardiac function and cardiovascular events. Methods Three groups of AMI patients were selected from July,2009 to December,2010.In group A are patients with elevated ST segment and undergoing emergent PCI treatment within 12 hrs after onset（n=46）;in group B are patients undergoing selective PCI treatment during their hospitalization（N=42）;in group C are patients of AMI being hospitalized within 24 hrs after onset and without PCI treatment（n=34）.The plasma NT-proBNP was measured by electrochemiluminescence and ultrasound electrocardiogram examinations were carried out at different time after MI（myocardial infarction） in these patients.The cardiovascular incidents of Group A,B and C were recorded for the following 6 months. Results The NT-proBNP value examined each time of Group A patients was significantly lower than that of group B and C（p0.05）;the NT-proBNP value of Group B 11 days after MI and later was lower than Group C（p0.05）.The difference in cardiac function between Group A and B,Group A and C,Group B and C was quite obvious on the 45th day and 6 months later（p0.05）;Group differences in cardiac incidents among three groups were statistically significant（p0.05）. Conclusion The NT-proBNP value in AMI patients decline obviously after emergent or selective PCI,and may be used as the predictor of cardiac function of patients;both emergent and selective PCI can decline the cardiovascular incidents,but emergent PCI distinctly outweighs selective PCI.

作者刘向阳唐良秋江志平张社兵李爱华万槐斌范文茂陈宝峰

机构地区粤北人民医院

出处《现代医院》 2012年第2期23-25,共3页 Modern Hospitals

基金韶关市医药卫生科研计划项目(编号:Y10022)

关键词急性心肌梗死经皮冠状动脉介入治疗氨基末端脑钠肽前体心功能心血管事件 Acute myocardial infarction Percutaneous coronary intervention N-Terminal Pro-Brain natriuretic peptide Cardiac function Cardiovascular events

分类号 R654.2 [医药卫生—外科学]

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