摘要
目的:寻找肝纤维化等慢性肝病敏感可靠的血清学诊断指标。方法:对196例各型肝病联合检测血清透明质酸(HA)、脯氨酸肽酶(PLD)、Ⅲ型前胶原(PCⅢ)、层粘蛋白(LN)、Ⅳ型胶原(Ⅳ-C),并与10例肝组织学和30例健康献血员做对照研究。结果:五项指标分别在急性肝炎、慢性肝炎和肝硬变中依次升高,差异显著(P<0.05或P<0.01),其改变情况与轻、中、重型纤维化程度呈同步性,有良好的正相关。结论:五项指标联合检测可极大地增加慢性肝病临床诊断的准确性与可靠性,动态观察其变化可掌握病情演变。
Objective The study was designed to estabish sensitive and reliable serum marker on liver fibrosis etc. Chronic hepatic diseases for early clinical diagnosis, Methods We carried out co- detection of serum HA, PLD, PCIII, LN and IV - c in 196 cases with different hepatic diseases compared with liver - biopsy samples of 10 cases and 30 cases health volunteer blood. Results The five markers increase in the acute virus hepatitis, chronic hepatitis and cirrhosis progressively while the difference between groups were significant (P<0. 05 or P<0. 01). Conclusion The co - detection of five markers Can improve the accurency and reliability of clinical diagnosis. The dynamic changement of five markers may be used to predict the. trends of diseases.
出处
《医学研究通讯》
2000年第2期13-15,共3页
Bulletin of Medical Research
关键词
肝纤维化
透明质酸
脯氨酸肽酶
Ⅲ型前胶原
诊断
Liver fibrosis Hyaluronate acid Prolidase Serum type III procollagen Laminin Collagen type IV
