期刊文献+

盐酸罗格列酮治疗2型糖尿病的效果观察 被引量:7

暂未订购
导出
摘要 目的观察探讨盐酸罗格列酮治疗2型糖尿病的临床疗效,总结其临床价值。方法选取2009年7月至2011年1月收治的2型糖尿病患者96例,分别给予口服盐酸罗格列酮4mg/d,持续12周为1个疗程,比较治疗前后的血糖、血脂、体重指数及糖化血红蛋白的变化,进行统计学分析。结果 96例患者治疗前后血糖、血脂、胰岛素抵抗及糖化血红蛋白水平的变化比较差异有统计学意义(P<0.05),治疗后各代谢指标有明显改善。结论盐酸罗格列酮治疗2型糖尿病疗效显著,能有效降低血糖、血脂和改善胰岛素抵抗,极少发生低血糖事件,对体重几乎无影响,安全可靠,值得在临床上合理推广应用。
作者 马飞
机构地区 广东省人民医院
出处 《河北医药》 CAS 2012年第5期674-675,共2页 Hebei Medical Journal
  • 相关文献

参考文献2

二级参考文献13

  • 1王静,谭擎缨,阮芸,阮勇.马来酸罗格列酮对2型糖尿病患者的长期疗效与安全性的观察[J].中国糖尿病杂志,2006,14(3):166-168. 被引量:6
  • 2NESTO R W,BELL D,BONOW R O,et al.Thiazolidinedione use,fluid retention,and congestive heart failure:a consensus statement from the American Heart Association and American Diabetes Association.October 7,2003[J].Circulation,2003,108(23):2941-2948.
  • 3ROSENSTOCK J,SHEN S G,GATLIN M R,et al.Combination therapy with nateglinide and thiazolidinedione improves glycemic control in type 2 diabetes[J].Diabetes Care,2002,25(9):1529-1533.
  • 4KELLY I E,HANS T S,WALSH K,et al.Effects of a thiazolidinediones compound on body fat and fat distribution of patients with type 2 diabets[J].Diabetes Care,1999,22(3):288-293.
  • 5VIRKAMAKI A,UEKI K,KAHN C R.Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance[J].J Clin Invest,1999,103(7):931-943.
  • 6HERZ M,JOHNS D,REVIRIEGO J,et al.A randomized,doubleblind,placebo-controlled,clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus[J].Clin Ther,2003,25 (4):1074-1095.
  • 7KELLEY D E,BRAY G A,PI-SUNYER F X,et al.Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes:a 1-year randomized controlled trial[J].Diabetes Care,2002,25 (6):1033-1041.
  • 8Todd M K, Watt M J, Le J,et al. Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid induced inflammation and insulin resistance [J]. Am J Physiol Endocrinol Metab, 2007,292(2): E485-E493.
  • 9Mooradian A D, Chehade J, Thurman J E. The role of thiazolidinedionesin the treatment of patients with type 2 diabetes mellitus[J]. Treat Endocrinol, 2002,1 ( 1 ) : 13-20.
  • 10Derosa G, D Angelo A, Ragonesi P D,et al. Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome trealed with metformin[J]. Intern Med J, 2007,37(2):79-86.

共引文献10

同被引文献47

引证文献7

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部