摘要
检索雷公藤多苷片(glucoside tripterygium total,GTT)致肝损伤及其增效减毒的相关文献,探讨GTT使用剂量和时间与肝损伤发生的相关性。归纳具有保肝作用的单体或动植物有效成分,分析GTT与这些药物相互作用机制。讨论GTT的肝损伤机理和增效减毒机理,以及预防措施。为临床安全应用GTT提供循证依据。
Correlated literatures of the liver injury induced by glucoside tripterygium total（GTT） and of its synergism and toxicity reducing effects were retrieved to study the correlation between the dosage,the time point of GTT and the liver injury.The monomer or active ingredients of animals and plants with the hepatoprotective effect were included.The mechanisms of action between GTT and these drugs were analyzed.The mechanism for GTT induced liver injury and its synergism and toxicity reducing mechanisms,as well as the preventive measures were discussed,thus providing evidence-based basis for safe clinical application of GTT.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2012年第3期415-418,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
江苏省中医药领军人才项目(No.LJ200907)
关键词
雷公藤多苷片
肝毒性
增效减毒
文献分析
glucoside tripterygium total
hepatotoxicity
synergism and toxicity reducing
literature analysis
