摘要
氰戊菊酯和甲苯以4:5混合时,对个鼠的致死作用、遗传效应和大鼠肺泡巨噬细胞的毒性均存在拮抗作用。文中对拮抗机理进行了讨论,制订卫生标准时应考虑两者的拮抗性。
This paper reports the joint toxicity of Fenva- ierate (Fen) and Toluene (Tol) on the multiple system of rats and mice. The types of joint action were determinded by Keplinger's standard and Fa- ctorial analysis. Fen and Tol mixture (4:5 mixed by weight) was simulating the formulation of Fen pe- sticide that used practically in China. When the mice were exposed (by intratracheal injection) to the mixture, the intoxicated symptoms were less than those exposed to single chemical, especially Fen. The ratio of the expected LD_(50) to the obse- rved LD_(50) was 0. 22 (<0.57), which belong to the antagonism. There was an marked antagonism bet- ween these two chemicals on the genotoxicity9 such as the rate of the micronucled in mice bone marrow polychromatic erythrocytes, and on the cytotoxicity of the rats pulmonary alveolar macrophages. But on motor conduction latency rate of Sciatic Nerve, the two chemicals didn't show antagonistic effect. The mechanism of this antagonism is probably related to the inducing effect of Tol to MFO that is main enzyme of Fen matabolism. It's important to keep in mind the characteristic of the antagonism of chemicals while one wish to formualate health cri- teria of these chemicals.
关键词
氰戊菊酯
联合毒性
甲苯
Fenvalerate Toluene Joint toxicity
