摘要
本文对湖北省仙桃地区农村流行的肠病性肢端皮炎作了较深入的环境流行病学研究。结果表明病儿家族中患同样疾病的人极显著的高于对照组;外环境水、土壤及大米中锌含量测定,证实当地并非锌缺乏地区;生物样品分析显示患儿血锌含量显著低于农村健康婴幼儿、后者又显著低于城镇婴幼儿,患儿母乳锌比农村健康婴幼儿母乳锌也明显偏低,提示当地农村婴幼儿可能普遍锌缺。由于患儿血锌过低,以致出现血铜升高,血清碱性磷酸酶活性降低,患儿经补锌治疗后,上述变化均可迅速纠正。
The study of environmental epidermiology of acrodermatitis enteropathica, which was prevalent in rural area, Xiantao Hubei was made thoroughly. The results showed that the numbers of the infants who had family history and suffered from the dis- ease were signifcantly more than those of the con- trol families. The measurement of Zinc content in water, soll and rice confirmed that the area ment- ioned above is not deficient in Zinc. The biological samples determination showed that the content of Zinc in sick infant blood was signifcantly less than that of healthy infants in rural area, and the latter was signifcantly less than that of infants and children in city. In the same area the content of Zinc in the milk of sick infants' mothers was signifca- nfly less than than of healthy infant mothers. It indicated the possibility that the healthy infants in the rural area were general potential deficient in Zinc. The lower level of Zinc in sick infant blood leaded to the increasing of blood copper, the decreasing of activity of Alkaline Pltosphatase (AKP) and the content of IgG antibody in blood- serum. But these symptoms would disappear imm- ediately after supply Zinc to sick infants.
