摘要
目的探讨促性激素释放激素受体（GnRHR）和表皮生长因子受体（EGFR）在胃癌组织中的表达及临床意义。方法应用免疫组织化学SP及原位定量法，对31例胃癌组织中GnRHR、EGFR的表达进行检测及半定量分析。结果胃癌不同分化程度的癌组织均显示GnRHR和EGFR阳性免疫反应，GnRHR表达阳性28例（90．32％），EGFR表达阳性15例（48．39％），原位定量显示GnRHR的表达高分化14例、中分化9例、低分化5例，随着组织分化程度增高而增高；EGFR的表达高分化3例、中分化5例、低分化7例，随着组织分化程度增高而降低（P〈0．05），并且GnRHR较EGFR阳性免疫反应强。结论GnRHR与EGFR的表达量可能与胃癌的发生及发展有关。
Objective To investigate the expressions of gonadotropin-releasing hormone receptor（GnRHR） and epidermal growth factor receptor（ EGFR） in gastric carcinoma and to explore its clinical significance. Methods The expressions of GnRHR and EGFR in 31 cases of gastric carcinoma were observed by SP immunohistochemical method and the method of in situ quantification. Results The GnRHR and EGFR positive immunoreactive substances were located in the tumor cells of gastric carcinoma, GnRHR 28 cases （90. 32% ）, EGFR 15 cases （48.39%）, the expression of GnRHR increased in accordance with histologic differentiation, well-differentiated 14 cases, moderately differentiated 9 cases, poorly differentiated 5 cases, the expression of EGFR decreased in accordance with its increasing degree of histologic differentiation, well-differentiated 3 cases, moderately differentiated 5 cases, poorly differentiated 7 cases, （ P 〈 0. 05 ）, and GnRHR was more obvious than EGFR in immunoreaction. Conclusion GnRHR and EGFR could be related to the pathogenesis and the development of the gastric carcinoma.
出处
《中国基层医药》
CAS
2012年第4期524-526,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胃肿瘤
受体
促性激素释放激素
Stomach neoplasms
Receptors
Gonadotropin-releasing hormone
