摘要
目的探讨丙戊酸钠治疗外伤性癫痫复发后，比较添加卡马西平或拉莫三嗪联合治疗外伤性癫痫效果。方法采用开放性试验的方法对131例丙戊酸钠治疗外伤性癫痫复发患者，进行卡马西平或拉莫三嗪联合丙戊酸钠治疗，以治疗前3个月癫痫发作频度为对照，对治疗6个月后的疗效、不良反应及安全性进行自身对比观察。结果应用卡马西平或拉莫三嗪联合丙戊酸钠治疗6个月后，患者发作频率均较用药前明显减少；发作频率减少≥50％的患者分别为72．6％和91．3％，差异有统计学意义（P〈0．01）；卡马西平联合丙戊酸钠不良反应的发生率为37．1％，拉莫三嗪联合丙戊酸钠不良反应的发生率为8．7％。结论拉莫三嗪联合丙戊酸钠治疗外伤性癫痫复发疗效确切，不良反应轻微。
Objective To explore the effect of depakine in the treatment of traumatic epilepsy relapse, and compared carbamazepine and lamotrigine combined with depakine in the treatment of traumatic epilepsy. Methods Open trial in 131 patients with traumatic epilepsy relapse treated with depakine, and all patients were aderministered with carbamazepine or lamotrigine combined with depakine. 3 months before treatment, the epilepsy seizures frequency was compared, and 6 months after the treatment,the efficacy, adverse reactions and safety was compared between two mothods. Results Application of carbamazepine or lamotrigine combined with depakine treatment for 6 months, the seizure frequency significantly decreased compared with before treatment; The seizure frequency reduction（ ≥50% ） were 72.6% and 91.3% ,the difference was statistically significant between before and after treatment （P 〈 0.01 ） ; The adverse reactions of carbamazepine combined with depakine was 37.1%, and it of lamotrigine combined with depakine was 8.7%. Conclusion Lamotrigine combined with depakine in the treatment of traumatic epilepsy recurrence was effective, and its side effects was light.
出处
《中国基层医药》
CAS
2012年第3期329-330,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
江苏省昆山市社会发展项目基金（KS1006和KS1009）
关键词
拉莫三嗪
卡马西平
癫痫
Lamotrigine
Carbamazepine
Epilepsy
