摘要
目的 探讨急性重症胆管炎 (acutecholangitisofseveretype ,ACST )患者胆汁和外周血中内皮素(endothelin ,ET)的变化与肝胆系统和全身病理损害的关系。方法 对 2 5例ACST患者术中、术后 7天、14天胆汁和外周血中ET、谷丙转氨酶 (ALT)和总胆红素进行了动态测定。结果 术后 7天、14天上述指标明显降低 (P <0 .0 5和P <0 .0 1) ,外周血和胆汁中ET浓度变化呈平行关系。结论 ET与ACST病理过程密切相关 ;
Objective To evaluate the relationship between endothelin (ET) in bile and peripheral blood with systemic and hepatobiliary injury in patients with acute cholangitis of severe type (ACST). Methods ET, ALT and total bilirubin in bile and peripheral veinous blood of 25 patients with acute cholangitis of severe type (ACST) were detected during operation, one week and two weeks after operation. Results The contents of ET, ALT and total bilirubin were significantly lower on 7 day and 14 day after operations as compared with that during operations ( P <0.05 and P <0.01). The concentration of ET in peripheral veinous blood paralleled with that in bile.Conclusion This suggests that ET is tightly related with the pathologic process of ACST. So, in patients with ACST, the dynamic measurement of ET in peripheral veinous blood can be an index for judging the degree of pathological damage either to the hepatobiliary or systemic systems.
出处
《中国普外基础与临床杂志》
CAS
2000年第2期91-93,共3页
Chinese Journal of Bases and Clinics In General Surgery
