摘要
目的探讨支气管哮喘患者外周血中内皮素(ET-1)、血栓素B2(TXB2)的动态变化及临床意义。方法支气管哮喘急性发作期患者75例(其中轻度42例,中重度33例),健康对照组38例。采用放射免疫法测定血浆中ET-1、TXB2的水平。结果 1、血浆中ET-1、TXB2水平轻度与中重度哮喘组患者高于健康对照组,差异有统计学意义(P<0.01)。中重度哮喘组高于轻度组,差异有统计学意义(P<0.01)。2、哮喘组血浆中ET-1与TXB2水平呈正相关(r=0.601,P<0.01)。结论 ET-1、TXB2可能在哮喘的急性发病过程中起作用,以及影响哮喘的发生、发展。
Objective Discuss the change and clinical significance of the endothelin（ET-1）,Thrombosis element B2（TXB2） in the plasma of asthma patients.Method 75 Patients with acute asthma（42 lighter patients,33 patients with moderate and severe degree disease）was studied and compared with a control group of 38 healthy individuals.Radioimmunoassay was used to determine the plasma level of ET-1,TXB2.Results 1.There were statistically significances differences between moderate and severe group and the normal group in ET-1 and TXB2 level（P0.01）.A difference was also observed between the moderate and light degree group.2.ET-1 level in the plasma of asthma patients is proportional to the level of TXB2（r=0.601,P0.01）.Conclusion ET-1、TXB2 may play a role in the pathogenesis of of acute asthma,and affect the the occurrence and development of asthma.
出处
《临床肺科杂志》
2012年第4期621-622,共2页
Journal of Clinical Pulmonary Medicine
关键词
哮喘
内皮素-1
血栓素B2
asthma
endothelin-1（ET-1）
Thrombosis element B2（TXB2）
