摘要
目的:观察应用阿卡波糖干预治疗糖耐量减低(IGT)患者的临床疗效,协助临床控制糖耐量以减低患者向2型糖尿病的转变。方法:对120例糖耐量减低患者随机分为治疗组和对照组各60例,两组均予饮食和运动干预,治疗组加用阿卡波糖,12个月后比较两组患者糖尿病发生率以及体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、葡萄糖耐量试验(OGTT)2 h后血糖(2HPG)、空腹胰岛素(FINS)和OGTT 2 h后胰岛素(PINS)、胰岛素抵抗指数(IRI)和胰岛素敏感指数(ISI)等指标。结果:干预治疗1年后,对照组患者糖尿病的发病率为8.3%,阿卡波糖组的发病率为5.0%;治疗组BMI、WHR、FPG、2HPG、FINS、PINS以及IRI值均明显低于对照组,而ISI显著高于对照组,差异有统计学意义。结论:阿卡波糖能够降低IGT人群糖尿病的发病率,明显改善IGT患者的代谢紊乱因素。
Objective：To investigate the therapeutic effects of Acarbose on patients with impaired glucose tolerance （IGT）, assisting to prevent these IGT patients into development of Type 2 diabetes mellitus （T2DM）. Methods： 120 IGT patients were enrolled and divided randomly into 2 groups ： treatment and control group, and the diet and exercise were controlled for both groups of patients. After 1 year,the diabetes incidence were compared and the indices were assayed in the two groups including body mass index （BMI）, waist/hip ratio （WHR）, fasting plasma glucose （FPG）, plasma glucose 2 hours after oral glucose tolerance test （ 2HPG）, fasting and 2 - hour - after - OGTT insulin level （ FINS and PINS）, insulin resistance index （IRI） and insulin sensitivity index （ISI） . Results：The diabetes incidence was 8.3% in control group and 5% in treatment group;compared to the control group,the BMI, WHR, FPG,2HPG, FINS, PINS and IRI were decreased, and the ISI was increased. Conclusion： Application of Acarbose in IGT subjects can reduce the incidence of diabetes, and obviously improve the factors for metabolic disorder.
出处
《天津药学》
2012年第1期22-24,共3页
Tianjin Pharmacy
关键词
阿卡波糖
干预
糖耐量异常
糖尿病
acarbose, intervention, impaired glucose tolerance, diabetes mellitus
