摘要
目的优化葛根素分散片的制备工艺及考察其体外溶出度。方法采用正交试验法,以崩解时限为指标,考察微晶纤维素(MCC)+低取代羟丙基纤维素(L-HPC)的质量分数、交联聚乙烯吡咯烷酮(PVPP)的质量分数和硬脂酸镁的质量分数3个因素对崩解时限的影响,以筛选最优处方;并采用紫外分光光度法对分散片的体外溶出度进行考察。结果最优处方:MCC+L-HPC的用量为20%,PVPP的用量为1.5%,硬脂酸镁的用量为0.8%;按优化后的处方工艺制备的葛根素分散片的崩解时间为25 s,分散均匀性好,药物30 min内基本溶出。结论所制备的葛根素分散片具有溶散快、分散均匀、溶出速率快的特性,适于临床应用需要。
Objective To optimize the preparation process of dispersible tablets of puerarin and evaluate its dissolution rate in vitro.Methods Orthogonal experiment was performed with disintegration time as index,in which microcrystalline cellulose（MCC）＋L-hydroxypropylcelulose（L-HPC）,polyvinylpyrrolidone（PVPP）and magnesium stearate were investigated for the optimal formula.The dissolution rate of dispersible tablets in vitro was determined by UV-spectrophotometry.Results The optimal formula was as follows： MCC＋L-HPC 20%,PVPP 1.5%,magnesium stearate 0.8%.The dispersible tablets disintegrated in 25 s,and the dispersible uniform was excellent.The drug was completely released within 30 min.Conclusion The dispersible tablets of puerarin have a fast,homogeneously dispersing profile and good releasing characteristics,which is suitable for clinical needs.
出处
《广东药学院学报》
CAS
2011年第6期555-558,共4页
Academic Journal of Guangdong College of Pharmacy
关键词
葛根素
分散片
正交试验
溶出度
puerarin
dispersible tablet
orthogonal experiment
dissolution rate
