摘要
目的:对比四种成盐剂对头孢噻肟钠成品质量的影响。方法:通过头孢噻肟酸与成盐剂反应制得头孢噻肟钠溶液,再滴加丙酮析出头孢噻肟钠固体。结果:由碳酸氢钠制得的头孢噻肟钠质量优于其他方法。结论:使用碳酸氢钠作成盐剂,滴加丙酮结晶,简化了工艺路线,并能有效地降低生产成本,减少环境污染,适合工业化生产。
Objective： To compare four kinds of salifying reagent＇s effect on quality of Cefotaxime Sodium product. Methods： Make solution of Cefotaxime Sodium by salifying reaction of Cefotaxime acid, and then dropping acetone to make Cefotaxime Sodium precipi- tated. Results： The quality of Cefotaxime Sodium obtained from the sodium bicarbonate is better than other methods. Conclusion： The use of sodium bicarbonate and dropping acetone to crystallize simplifies the process. This method can effectively reduce production costs, reduce environmental pollution, and it＇s more suitable for industrial production than others.
出处
《黑龙江科技信息》
2012年第6期24-24,共1页
Heilongjiang Science and Technology Information
关键词
头孢噻肟钠
碳酸氢钠
丙酮
成盐
Cefotaxime Sodium
Sodium bicarbonate
Acetone
Salifying
