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Wnt/β-catenin信号通路在髓鞘发育和再生过程中的作用 被引量：3

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摘要 多条信号通路共同调控少突胶质细胞分化成熟而促进髓鞘发育和再生。其中,Wnt/β-cate-nin信号通路抑制少突胶质细胞的分化成熟,在髓鞘发育和损伤修复过程中发挥着负性调节作用。胞外Wnt激活及抑制信号、糖原合成酶激酶-3β的活性、β-catenin的核浆转运是Wnt/β-catenin信号通路的关键环节,通过有效调控上述环节而促进髓鞘再生是髓鞘修复领域的前沿问题。
作者 任远 王晗知 肖岚
机构地区 第三军医大学学员旅 第三军医大学组织学与胚胎学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第1期71-74,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(31000482) 国际科技合作计划(2010DFB30820)资助课题
关键词 少突胶质细胞 WNT/Β-CATENIN信号通路 髓鞘再生 分化
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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同被引文献49

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生理科学进展
2012年 第1期

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