摘要
用动态配气设备和鼻式吸入方式染毒,采用雄性豚鼠对环境中10种挥发性污染物(苯、甲苯、对二甲苯、乙基苯、氯代苯、苯乙烯、异丙苯、四氯乙烯、甲基环己烷和壬烷混合物)的吸入动力学进行了研究。用固相微萃取气相色谱(SPME-GC)法同时测定了血中这10种化合物浓度的经时变化规律。用线性房室模型评价了这些物质的代谢动力学。代谢动力学研究数据表明,低浓度苯乙烯较四氯乙烯更易吸收。同时用代谢动力学参数外推出在不同的暴露浓度下其代谢物的消除量。线性双室模型表明,在低浓度暴露下苯(121μg/m3)的吸收量所占环境浓度的比例为高浓度苯(12.1mg/m3)的4.8倍。因此,尽管对于所有化合物的暴露浓度是相等的,但在评价化合物的危险性时,不仅要考虑单个化合物的吸收量,而且还应考虑其在体内的代谢速率。本研究为评价这些物质在低浓度长期暴露下的危险性提供了最基本的数据。
A dynamic generating toxic gas system and a nose only exposure system were used for the pharmacokinetic study of inhaled environmental contaminants for benzene, toluene, xylene, ethylbenzene, chlorobenzene, styrene, isopropyl benzene, tetrachloroethylene, nonane and methylcyclohexane in male guinea pig. The change of these substances in blood with time was determined simultaneously by solid phase micro extraction(SPME) gas chromatography (GC). The results showed that the fraction of absorption of benzene at low(121 μg/m 3) exposure was 4 8 times higher than that at high(12 1 mg/m 3) exposure. The pharmacokinetics of these substances were evaluated by using linear compartment models.The data showed that more styrene was absorbed than tetrachloroethylene at low exposure. The metabolic elimination of these compounds at various exposure concentrations was extrapolated by using estimated pharmacokinetic parameters. Moreover, not only should the differences in absorption quantities be considered in evaluation of potential risk assessment, the metabolic elimination rates should also be considered although the exposure concentrations in gas for all chemicals were equal. The data presented in this paper was fundamental data used for risk assessment.
出处
《卫生研究》
CAS
CSCD
北大核心
2000年第2期99-101,共3页
Journal of Hygiene Research
