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Hedgehog信号通路与前列腺癌的关系

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摘要 Hedgehog（Hh）基因首先是由C.NussleinVolhard和E.Wieschaus于1980年在黑腹果蝇（Drosophila）身上进行研究时,发现当这类因子发生突变时,果蝇幼虫表皮上会长满小的倒刺,形似＂刺猬＂,故命名＂刺猬＂（Hedgehog）[1]。Hh信息通路的异常激活可以在脑、肺、胃肠及皮肤等部位产生恶性肿瘤，可能是因为肿瘤干细胞需要Hh信号来维持他们的增殖和分化，选择性地阻断这一通路可以抑制肿瘤的生长，表明Hh通路对肿瘤的生长起着核心作用。
作者 罗荣利 史子敏 朱安义
机构地区 南昌大学第二附属医院泌尿外科
出处 《南昌大学学报（医学版）》 CAS 2011年第12期97-100,共4页 Journal of Nanchang University：Medical Sciences
关键词 信号转导 前列腺癌 HEDGEHOG信号通路 CYCLOPAMINE
分类号 R737.25 [医药卫生—肿瘤]
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参考文献27

  • 1朱刚,刘明,万奔.早期前列腺癌的诊断与治疗[J].中华男科学杂志,2005,11(9):693-696. 被引量：31
  • 2张灵,计国义,李晓萌,李胜文,高洪文,甘卉,王洪亮,潘玉琢,孔祥波,桑原正明,赵雪俭.前列腺癌集团检诊对临床前列腺癌诊断的影响[J].中华泌尿外科杂志,2004,25(2):103-105. 被引量：41
  • 3Narita S,So A,Ettinger S,et al.GLl2knockdown using an an-tisense oligonucleotide induces apoptosis and chemosensitizescells to paclitax-el in androgen-independent prostate cancer. Clinical Cancer Research . 2008
  • 4Azoulay S,Terry S,Chimingqi M.et al.Comparative expres-sion of Hh ligands at different stages of prostate carcinomaprogression. Journal of Paleopathology . 2008
  • 5Vanchieri C.Scientists hopeful as they uncover molecular cluesto Prostate cancer. Journal of the National Cancer Institute . 2005
  • 6Kasper M,Red G,Frischauf A M,et al.GLI transcription fac-tors:mediators of oncogenic Hedgehog signaling. European Journal of Cancer . 2006
  • 7Podlasek C A,Barnett D H,Clemens J Q,et al.Prostate de-velopment requires Sonic hedgehog expressed by the urogeni-tal sinus epithelium. Developmental Biology . 1999
  • 8Lamm M L,Catbagan W S,Laciak R J,et al.Defects in mousemammary gland development caused by conditional haploin-sufficiency of Patched-1. Developmental Biology . 2002
  • 9Shaw G,Price A M,Ktori E,et al.Hh signalling in androgenindependent prostate cancer. Ear Urol . 2008
  • 10Barnett D H,Huang H Y,Wu X R,et al.The human prostateexpresses sonic hedgehog during fetal development. The Journal of Urology . 2002

二级参考文献25

  • 1Kaplan ID, Cox RS, Bagshaw MA. Prostate specific antigen after external beam radiotherapy for prostatic cancer: followup[J]. J Urol, 1993, 149(3):519-522.
  • 2Oefelein MG, Smith N, Carter M, et al. The incidence of prostate cancer progression with undetectable serum prostate specific antigen in a series of 394 radical prostatectomies[J]. J Urol, 1995, 154(6):2128-2131.
  • 3Schild SE, Wong WW, Novicki DE, et al. Detection of residual prostate cancer after radical prostatectomy with the Abbott IMx PSA assay[J]. Urology, 1996, 47(6):878-881.
  • 4Crook JM, Bahadur YA, Bociek RG, et al. Radiotherapy for localized prostate carcinoma. The correlation of pretreatment prostate specific antigen and nadir prostate specific antigen with outcome as assessed by systematic biopsy and serum prostate specific antigen[J]. Cancer, 1997, 79(2):328-336.
  • 5American Society for Therapeutic Radiology and Oncology Consensus Panel. Consensus statement: guidelines for PSA following radiation therapy[J]. Int J Radiat Oncol Biol Phys, 1997,37(3):1035-1041.
  • 6Cooperberg MR, Broering JM, Litwin MS, et al. CaPSURE Investigators. The contemporary management of prostate cancer in the United States: lessons from the cancer of the prostate strategic urologic research endeavor (CapSURE), a national disease registry[J]. J Urol, 2004, 171(4):1393-1401.
  • 7American cancer society. Cancer facts and figures 2003[M]. Atlanta, GA: American Cancer Society.2001.48-51.
  • 8Parkin DM, Muir CS, Whelan SL. Cancer incidence in five continents [M]. Vol 6. IARC Scientific Pub. No 120. Lyon, France: International Agency of Research on Cancer. 1992.76-79.
  • 9Jemal A, Thomas A, Murray T, et al. Cancer statistics, 2002[J]. CA Cancer J Clin, 2002, 52(1):23-47.
  • 10Thompson IM, Ernst JJ, Gangai MP, et al. Adenocarcinoma of the prostate: results of routine urological screening[J]. J Urol, 1984, 132(4):690-692.

共引文献69

南昌大学学报（医学版）
2011年 第12期

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