摘要
目的探讨儿童急性淋巴细胞性白血病(ALL)微小残留病(MRD)与临床和预后的关系。方法 102例儿童急性B系淋巴细胞性白血病按照ALL-XH-99方案分为低危(low risk,LR)组28例、中危(medium risk,MR)组50例、高危(high risk,HR)组24例。所有患儿均接受ALL-XH-99方案化疗,并随访6～28个月。在诱导治疗结束获CR、化疗6个月时利用CD45/SSC双参数图设门的三色流式细胞术(FCM)进行MRD监测。结果诱导治疗结束获CR及化疗6个月时3组MRD阳性率比较差异有统计学意义(P<0.05或P<0.01),其中HR组MRD阳性率明显高于MR、LR组(P<0.05或P<0.01);MRD阳性者的复发率明显高于MRD阴性者(P<0.05或P<0.001)。结论检测MRD有助于判断儿童ALL的疗效及预后。
Objective To explore the relationship of minimal residual disease（MRD） in childhood acute lymphoblastic leukemia（ALL） to the clinic and prognosis.Methods A total of 102 cases of MRD in childhood ALL（28 cases in low-risk group,50 in medium-risk group and 24 in high-risk group）were treated with ALL-XH-99 protocol and were followed-up for 6-28 months.CD45/SSC gating dual-parameter three-color flow cytometry（FCM） was used to monitor MRD in children who achieved CR at the end of induction therapy or at 6 months after initiating chemotherapy.Results There were significant differences in MRD-positive rate among the three groups at the end of induction therapy and at 6 months after initiating chemotherapy（P0.05 and P0.01,respectively）.MRD-positive rate in high-risk group was significantly higher than that in medium-risk group or low-risk group（P0.05 and P0.01）.Moreover,the relapse rate in MRD-positive patients was obviously higher than that in MRD-negative patients（P0.05 and P0.001）.Conclusion The detection of MRD can help to determine the efficacy and prognosis of childhood ALL.
出处
《南昌大学学报（医学版）》
CAS
2011年第12期39-41,共3页
Journal of Nanchang University：Medical Sciences
关键词
急性淋巴细胞性白血病
微小残留病
预后
复发
儿童
acute lymphoblastic leukemia
minimal residual disease
prognosis
relapse
children
