摘要
目的 观察膀胱癌中 MDM2和 p5 3蛋白的表达状况及意义。方法 用免疫组化检测 70例原发性膀胱移行细胞癌 (TCC)中 MDM2和 p5 3蛋白的过度表达情况。结果 MDM2核免疫阳性 44 .2 9% (31/ 70 ) ,32例 (45 .71% )p5 3核染色阳性 ,两者共同阳性 9例。 MDM2表达是膀胱癌的早期表现 ,p5 3蛋白与 MDM2相反 ,两者呈负相关 (r=-0 .5 34 6 ,0 .0 5 >P>0 .0 1)。结论 MDM2和 p5
Objective To observe and study the expression of MDM2 and p53 proteins and its significance in bladder cancers. Methods Using immuno histo chemical method to investigate the expression of MDM2 and p53 proteins in 70 cases of primary transitional cell carcinoma (TCC) of urinary bladder. Results MDM2 showed a nucleo immuno positive rate of 44 29 % (31/70), 32 cases showed a nuclear stain positive rate of 45 71 % of p53, and 9 cases showed both positive. Expression of MDM2 was an early manifestation of bladder cancers, however, p53 protein is just on the contrary and showed a negative correlation ( r= -0 5346, 0 05> P >0 01). Conclusion MDM2 and p53 proteins are an early and a late gene events in the occurrence and progress of bladder cancers.
出处
《肿瘤》
CAS
CSCD
北大核心
2000年第2期133-134,共2页
Tumor
