摘要
目的矽肺形成是一个慢性的、持续渐进过程,在整个形成过程中二氧化硅粉尘颗粒的大量、长期吸入是形成矽肺的基础。由各种自由基所诱导的脂质过氧化反应所致巨噬细胞和上皮细胞损伤是矽肺形成的前提。在矽肺形成过程中巨噬细胞增殖能力先增强后减弱,而肺巨噬细胞凋亡始终增加。纤维化细胞因子通过自分泌和旁分泌形成更多细胞因子,与其细胞表面相应受体构成信息链动传递并实施免疫交叉、协同调控作用是矽肺形成的关键。肺成纤维细胞大量增殖、胶原合成和细胞外基质产生是矽肺形成的重要因素。
The formation of silicosis is a chronic,continuous gradual process,in which the large number and long term inhalation of silica dust particles is the basis.The injury of macrophages and epithelial cells caused by lipid peroxidation,which is induced by various free radical,is the prerequisite for the formation of silicosis.In the process of silicosis formation,the proliferation of macrophages increases first and then decreases,while pulmonary macrophage apoptosis always increase.Fibrosis cytokines forming more cytokines through autocrine and paracrine to form the information chain with the relevent receptor on cell surface.The delivery and implementation of cross-immunity and co-regulation by information chain is the key for silicosis formation.Numerous proliferation of lung fibroblasts,collagen synthesis and the emergence of extracellular matrix are the important factors of silicosis formation.
出处
《职业卫生与病伤》
2011年第6期370-375,共6页
Occupational Health and Damage
关键词
矽肺
自由基
细胞凋亡
细胞因子
silicosis
free radical
cell apoptosis
cytokine
